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Home / Primary Antibodies / Polyclonal Antibodies

Anti-GAB2 Antibody Picoband®

SKU : BHA21004985

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Mfr.No.	A02386-3, A02386-3-10ug, A02386-3-Biotin, A02386-3-Cy3, A02386-3-Dylight488, A02386-3-Dylight550, A02386-3-Dylight594, A02386-3-FITC, A02386-3-HRP, A02386-3-APC, A02386-3-PE, A02386-3-iFluor647, A02386-3-carrier-free
Alternative Names	caspase 2, apoptosis-related cysteine peptidase
Background	GRB2-associated-binding protein 2 also known as GAB2 is a protein that in humans is encoded by the GAB2 gene. This gene is a member of the GRB2-associated binding protein (GAB) gene family. These proteins contain pleckstrin homology (PH) domain, and bind SHP2 tyrosine phosphatase and GRB2 adapter protein. They act as adapters for transmitting various signals in response to stimuli through cytokine and growth factor receptors, and T- and B-cell antigen receptors. The protein encoded by this gene is the principal activator of phosphatidylinositol-3 kinase in response to activation of the high affinity IgE receptor. Two alteatively spliced transcripts encoding different isoforms have been described for this gene
Clonality	Polyclonal
Cross Reactivity	No cross-reactivity with other proteins.
Description	Boster Bio Anti-GAB2 Antibody Picoband® catalog # A02386-3. Tested in ELISA, Flow Cytometry, WB applications. This antibody reacts with Human, Mouse. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Weste blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
Function	Involved in the activation cascade of caspases responsible for apoptosis execution. Might function by either activating some proteins required for cell death or inactivating proteins necessary for cell survival.
Host	Rabbit
Immunogen Region	E.coli-derived human GAB2 recombinant protein (Position: S162-R504).
Isotype	Rabbit IgG
Molecular Weight	90 kDa
Reactivity	Human, Mouse
Reconstitution	Adding 0.2 ml of distilled water will yield a concentration of 500 ug/ml.
Synonyms	Caspase-2; CASP-2; Neural precursor cell expressed developmentally down-regulated protein 2; NEDD-2; Protease ICH-1; Caspase-2 subunit p18; Caspase-2 subunit p13; Caspase-2 subunit p12; CASP2; ICH1; NEDD2
Tissue Specificity	Expressed at higher levels in the embryonic lung, liver and kidney than in the heart and brain. In adults, higher level expression is seen in the placenta, lung, kidney, and pancreas than in the heart, brain, liver and skeletal muscle.
Note	Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.

Uniprot	Q9UQC2
Gene Id	9846
Gene Name	GAB2

Conjugates	Biotin, Cy3, Dylight488, Dylight550, Dylight594, FITC, HRP, APC, PE, iFluor647, carrier-free

Concentration	Adding 0.2 ml of distilled water will yield a concentration of 500 ug/ml.
Form	Lyophilized
Purification	Immunogen affinity purified.
Storage	At -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months.Avoid repeated freezing and thawing.

Applications	WB, Flow Cytometry, ELISA
Description	Weste blot, 0.1-0.25 ug/ml, Human, Rat Flow Cytometry (Fixed), 1-3 ug/1x10⁶ cells, Human ELISA, 0.1-0.5 ug/ml, -

Reference	1. Bentires-Alj, M., Gil, S. G., Chan, R., Wang, Z. C., Wang, Y., Imanaka, N., Harris, L. N., Richardson, A., Neel, B. G., Gu, H. A role for the scaffolding adapter GAB2 in breast cancer. Nature Med. 12: 114-121, 2006. 2. Chapuis, J., Hannequin, D., Pasquier, F., Bentham, P., Brice, A., Leber, I., Frebourg, T., Deleuze, J.-F., Cousin, E., Thaker, U., Amouyel, P., Mann, D., Lendon, C., Campion, D., Lambert, J.-C. Association study of the GAB2 gene with the risk of developing Alzheimer's disease. Neurobiol. Dis. 30: 103-106, 2008. 3. Gu, H., Saito, K., Klaman, L. D., Shen, J., Fleming, T., Wang, Y.-P., Pratt, J. C., Lin, G., Lim, B., Kinet, J.-P., Neel, B. G. Essential role for Gab2 in the allergic response. Nature 412: 186-190, 2001.

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Combination SKU	Supplier No.	Conjugation	Size	Your price	Quantity
BHA21004985-1	A02386-3	-	100 ug	$370		Add to Cart
BHA21004985-2	A02386-3-10ug	Sample	10 ug	$99		Add to Cart
BHA21004985-3	A02386-3-Biotin	Biotin	100 ug	$570		Add to Cart
BHA21004985-4	A02386-3-Cy3	Cy3	100 ug	$570		Add to Cart
BHA21004985-5	A02386-3-Dylight488	Dylight488	100 ug	$570		Add to Cart
BHA21004985-6	A02386-3-Dylight550	Dylight550	100 ug	$570		Add to Cart
BHA21004985-7	A02386-3-Dylight594	Dylight594	100 ug	$570		Add to Cart
BHA21004985-8	A02386-3-FITC	FITC	100 ug	$570		Add to Cart
BHA21004985-9	A02386-3-HRP	HRP	100 ug	$570		Add to Cart
BHA21004985-10	A02386-3-APC	APC	100 ug	$670		Add to Cart
BHA21004985-11	A02386-3-PE	PE	100 ug	$670		Add to Cart
BHA21004985-12	A02386-3-iFluor647	iFluor647	100 ug	$670		Add to Cart
BHA21004985-13	A02386-3-carrier-free	carrier-free	100 ug	$370		Add to Cart

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