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Home / Antibodies

Anti-F4/80 ( monocytes / Macrophages), murine Antibody

SKU : BHA10925331

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Applied Biological Materials (abm) Inc.

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Mfr.No.	Y103412
Categories	Primary Antibodies
Clonality	monoclonal
Description	F4/80 antigen is a 160 kDa cell surface glycoprotein that is a member of the EGF TM7 family of proteins which shares 68% overall amino acid identity with human EGF module containing mucin like hormone receptor 1 (EMR1). Expression of F4/80 is heterogeneous and is reported to vary during macrophage maturation and activation. The F4/80 antigen is expressed on a wide range of mature tissue macrophages including Kupffer cells, Langerhans, microglia, macrophages located in the gut lamina propria, peritoneal cavity, lung, thymus, bone marrow stroma and macrophages in the red pulp of the spleen. F4/80 expression has also been reported on a subpopulation of dendritic cells but is absent from macrophages located in T cell areas of the spleen and lymph node. The ligands and biological functions of the F4/80 antigen have not yet been determined but recent studies suggest a role for F4/80 in the generation of efferent CD8+ve regulatory T cells. F4/80 ( monocytes / Macrophages) clone number CI:A3-1.
Formulation	Liquid
Host	Rat(Rt)
Guarantee	abm guarantees that all our Anti-F4/80 ( monocytes / Macrophages), murine Antibody will perform as described on this product webpage, if this is not the case we will provide you with a one-time replacement at no extra cost. Documentation and explanation of experiment conducted will be required when submitting a claim for replacement.
Immunogen	Peritoneal mouse macrophages
Isotype	IgG2b
Quantity	100 μg
Recommended Dilution	Suitable for use in Immunohistochemistry (Frozen 1:500, Paraffin 1:200), FACS, immunoprecipitation and Western Blot.
Relevance	This antibody is the only macrophage marker that is able to distinguish non-destructive from destructive inflammation processes in the pancreas. It is a unique histological marker of the progression from peri-insulitis to beta-cell destruction and diabetes in a mouse diabetes model.
Shipping Condition	Ice Packs
Species Reactivity	Mouse

Gene Name	F4-80 ( monocytes - Macrophages), murine
Clone No	Monoclonal Antibody

Concentration	1mg/ml
Purity	Affinity purified
Storage	This product is stable for several weeks at 4°C as an undiluted liquid. Dilute only prior to immediate use. For extended storage, aliquot contents and freeze at -20°C or below. Avoid cycles of freezing and thawing. Expiration date is one (1) year from date of receipt.
Storage Buffer	PBS pH 7.2 with 0.1% Sodium Azide
Storage Condition	-20C

Description	IHC ; IP ; WB

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SKU	Supplier No.	Size	Your price	Quantity
BHA10925331	Y103412	250 ug	$1020		Add to Cart

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