Anti-ESR2 Antibody

Mfr.No.	Y058037
Categories	Primary Antibodies
Cellular Localization	Nuclear
Clonality	polyclonal
Description	This gene encodes a member of the family of estrogen receptors and superfamily of nuclear receptor transcription factors. The gene product contains an N-terminal DNA binding domain and C-terminal ligand binding domain and is localized to the nucleus, cytoplasm, and mitochondria. Upon binding to 17beta-estradiol or related ligands, the encoded protein forms homo- or hetero-dimers that interact with specific DNA sequences to activate transcription. Some isoforms dominantly inhibit the activity of other estrogen receptor family members. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some of these variants has not been fully characterized.
Host	Rabbit
Immunogen	Synthetic peptide conjugated to KLH
Isotype	IgG
Quantity	100 µl
Reactivity	Mouse, Human
Recombinant	FALSE
Regulatory	RUO
Shipping Condition	Ice Packs

Buffer	PBS, pH 7.4 with 0.02% Sodium Azide
Concentration	100µg/100ul
Description	Specificity: ESR2 antibody detects endogenous levels of ESR2 protein. Not tested with other proteins Relevance: Estrogen Receptor beta is a recent discovery, initially cloned and characterized from testis. Estrogen Receptor beta is highly homologous to Estrogen Receptor alpha; the ligand and DNA binding domains are highly conserved, while the amino terminus (transactivation domain), has diverged significantly. Estrogen Receptor beta binds estrogen with high affinity and regulates estrogen specific gene activation through direct interaction with estrogen response elements (EREs).
Format	Liquid
Purity	Protein A purified
Storage	This product is stable for several weeks at 4°C as an undiluted liquid. Dilute only prior to immediate use. For extended storage, aliquot contents and freeze at -20°C or below. Avoid cycles of freezing and thawing. Expiration date is one (1) year from date of receipt.
Storage Condition	-20C

Applications

WB, ELISA

Description

Recommended dilutions Peptide ELISA: 1:40,000 WB: 1/200 - 1/1000 Not yet tested in other applications. Optimal dilutions/concentrations should be determined by the end user, WB ; ELISA

Dilution

ELISA	1:40,000
WB	1:200-1:1000

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SKU	Supplier No.	Size	Your price	Quantity
BHA10903576	Y058037	100 ul	$217.50		Add to Cart

Anti-ESR2 Antibody

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