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Home / Primary Antibodies / Polyclonal Antibodies

Anti-ERAB/HSD17B10 Antibody Picoband®

SKU : BHA21000234

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Mfr.No.	PB9336, PB9336-10ug, PB9336-Biotin, PB9336-Cy3, PB9336-Dylight488, PB9336-Dylight550, PB9336-Dylight594, PB9336-FITC, PB9336-HRP, PB9336-APC, PB9336-PE, PB9336-iFluor647, PB9336-carrier-free
Alternative Names	3-hydroxyacyl-CoA dehydrogenase type-2
Background	ERAB is also known as HSD17B10 or HADH2. This gene encodes 3-hydroxyacyl-CoA dehydrogenase type II, a member of the short-chain dehydrogenase/reductase superfamily. The gene product is a mitochondrial protein that catalyzes the oxidation of a wide variety of fatty acids and steroids, and is a subunit of mitochondrial ribonuclease P, which is involved in tRNA maturation. The protein has been implicated in the development of Alzheimer disease, and mutations in the gene are the cause of 17beta-hydroxysteroid dehydrogenase type 10 (HSD10) deficiency. Several alternatively spliced transcript variants have been identified, but the full-length nature of only two transcript variants has been determined.
Clonality	Polyclonal
Cross Reactivity	No cross-reactivity with other proteins
Description	Boster Bio Anti-ERAB/HSD17B10 Antibody Picoband® catalog # PB9336. Tested in Flow Cytometry, IF, IHC, ICC, WB applications. This antibody reacts with Human. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
Function	Functions in mitochondrial tRNA maturation. Part of mitochondrial ribonuclease P, an enzyme composed of MRPP1/TRMT10C, MRPP2/HSD17B10 and MRPP3/KIAA0391, which cleaves tRNA molecules in their 5'-ends. Catalyzes the beta-oxidation at position 17 of androge
Host	Rabbit
Immunogen Region	E.coli-derived human ERAB recombinant protein (Position: E48-P261). Human ERAB shares 87% and 88% amino acid (aa) sequence identity with mouse and rat ERAB, respectively.
Isotype	Rabbit IgG
Molecular Weight	25 kDa
Reactivity	Human
Reconstitution	Add 0.2ml of distilled water will yield a concentration of 500ug/ml.
Specificity	No cross reactivity with other proteins.
Synonyms	3-hydroxyacyl-CoA dehydrogenase type-2;1.1.1.35;17-beta-hydroxysteroid dehydrogenase 10;17-beta-HSD 10;1.1.1.51;3-hydroxy-2-methylbutyryl-CoA dehydrogenase;1.1.1.178;3-hydroxyacyl-CoA dehydrogenase type II;Endoplasmic reticulum-associated amyloid beta-peptide-binding protein;Mitochondrial ribonuclease P protein 2;Mitochondrial RNase P protein 2;Short chain dehydrogenase/reductase family 5C member 1;Short-chain type dehydrogenase/reductase XH98G2;Type II HADH;HSD17B10;ERAB, HADH2, MRPP2, SCHAD, SDR5C1, XH98G2;
Tissue Specificity	Ubiquitously expressed in normal tissues but is overexpressed in neurons affected in AD. .
Note	Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg NaN3.

Uniprot	Q99714
Gene Id	3028
Gene Name	HSD17B10
Subcellular Location	Mitochondrion .

Conjugates	Biotin, Cy3, Dylight488, Dylight550, Dylight594, FITC, HRP, APC, PE, iFluor647, carrier-free

Concentration	Adding 0.2 ml of distilled water will yield a concentration of 500 ug/ml.
Form	Lyophilized
Purification	Immunogen affinity purified.
Storage	Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Applications	Flow Cytometry, IF, IHC, ICC, WB
Description	Western blot, 0.1-0.5ug/ml Immunohistochemistry (Paraffin-embedded Section), 0.5-1ug/ml, By Heat Immunocytochemistry/Immunofluorescence, 2ug/ml Flow Cytometry (Fixed), 1-3ug/1x10⁶ cells

Reference	1. Deutschmann AJ, et al. Mutation or knock-down of 17beta-hydroxysteroid dehydrogenase type 10 cause loss of MRPP1 and impaired processing of mitochondrial heavy strand transcripts. Hum Mol Genet, 2014 Jul 1. 2. Yang SY, et al. Roles of 17beta-hydroxysteroid dehydrogenase type 10 in neurodegenerative disorders. J Steroid Biochem Mol Biol, 2014 Sep.

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Combination SKU	Supplier No.	Size	Conjugation	Your price	Quantity
BHA21000234-1	PB9336	100 ug	-	$370		Add to Cart
BHA21000234-2	PB9336-10ug	10 ug	Sample	$99		Add to Cart
BHA21000234-3	PB9336-Biotin	100 ug	Biotin	$570		Add to Cart
BHA21000234-4	PB9336-Cy3	100 ug	Cy3	$570		Add to Cart
BHA21000234-5	PB9336-Dylight488	100 ug	Dylight488	$570		Add to Cart
BHA21000234-6	PB9336-Dylight550	100 ug	Dylight550	$570		Add to Cart
BHA21000234-7	PB9336-Dylight594	100 ug	Dylight594	$570		Add to Cart
BHA21000234-8	PB9336-FITC	100 ug	FITC	$570		Add to Cart
BHA21000234-9	PB9336-HRP	100 ug	HRP	$570		Add to Cart
BHA21000234-10	PB9336-APC	100 ug	APC	$670		Add to Cart
BHA21000234-11	PB9336-PE	100 ug	PE	$670		Add to Cart
BHA21000234-12	PB9336-iFluor647	100 ug	iFluor647	$670		Add to Cart
BHA21000234-13	PB9336-carrier-free	100 ug	carrier-free	$370		Add to Cart

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