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Home / Primary Antibodies / Polyclonal Antibodies

Anti-EAAT2/GLT-1/SLC1A2 Antibody Picoband®

SKU : BHA21000258

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Mfr.No.	RP1065, RP1065-10ug, RP1065-Biotin, RP1065-Cy3, RP1065-Dylight488, RP1065-Dylight550, RP1065-Dylight594, RP1065-FITC, RP1065-HRP, RP1065-APC, RP1065-PE, RP1065-iFluor647, RP1065-carrier-free
Alternative Names	Excitatory amino acid transporter 2
Background	SLC1A2 is also known as EAAT2 or GLT-1. This gene encodes a member of a family of solute transporter proteins. The membrane-bound protein is the principal transporter that clears the excitatory neurotransmitter glutamate from the extracellular space at synapses in the central nervous system. Glutamate clearance is necessary for proper synaptic activation and to prevent neuronal damage from excessive activation of glutamate receptors. Mutations in and decreased expression of this protein are associated with amyotrophic lateral sclerosis. Alteatively spliced transcript variants of this gene have been identified.
Clonality	Polyclonal
Cross Reactivity	No cross-reactivity with other proteins
Description	Boster Bio Anti-EAAT2/GLT-1/SLC1A2 Antibody catalog # RP1065. Tested in IF, IHC, WB applications. This antibody reacts with Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Weste blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
Function	Transports L-glutamate and also L- and D-aspartate. Essential for terminating the postsynaptic action of glutamate by rapidly removing released glutamate from the synaptic cleft. Acts as a symport by cotransporting sodium.
Host	Rabbit
Immunogen Region	E.coli-derived human EAAT2 recombinant protein (Position: T461-K574). Human EAAT2 shares 96% amino acid (aa) sequence identity with both mouse and rat EAAT2.
Isotype	Rabbit IgG
Molecular Weight	65 kDa
Reactivity	Mouse, Rat
Reconstitution	Add 0.2ml of distilled water will yield a concentration of 500ug/ml.
Specificity	No cross reactivity with other proteins.
Synonyms	Excitatory amino acid transporter 2;Glutamate/aspartate transporter II;Sodium-dependent glutamate/aspartate transporter 2;Solute carrier family 1 member 2;SLC1A2;EAAT2, GLT1;
Note	Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2mg Na2HPO4, 0.05 mg NaN3.

Uniprot	P43004
Gene Id	6506
Gene Name	SLC1A2
Sequence	Belongs to the peptidase S1 family. Plasminogen subfamily.
Subcellular Location	Membrane; Multi-pass membrane protein.

Conjugates	Biotin, Cy3, Dylight488, Dylight550, Dylight594, FITC, HRP, APC, PE, iFluor647, carrier-free

Concentration	Adding 0.2 ml of distilled water will yield a concentration of 500 ug/ml.
Form	Lyophilized
Purification	Immunogen affinity purified.
Storage	Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Applications	IF, IHC, WB
Description	Weste blot, 0.1-0.5ug/ml, Mouse, Rat Immunohistochemistry(Paraffin-embedded Section), 2-5 ug/ml, Mouse, Rat Immunofluorescence, 5 ug/ml, Mouse, Rat

Reference	1. Jiménez-Jiménez FJ, et al. The solute carrier family 1 (glial high affinity glutamate transporter), member 2 gene, SLC1A2, rs3794087 variant and assessment risk for restless legs syndrome. Sleep Med, 2014 Feb. 2. Poletti S, et al. Effect of early stress on hippocampal gray matter is influenced by a functional polymorphism in EAAT2 in bipolar disorder. Prog Neuropsychopharmacol Biol Psychiatry, 2014 Jun 3. 3. Tanaka K. Role of glutamate transporters in the pathophysiology of major mental illnesses. Nihon Yakurigaku Zasshi, 2013 Dec.

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Combination SKU	Supplier No.	Size	Conjugation	Your price	Quantity
BHA21000258-1	RP1065	100 ug	-	$370		Add to Cart
BHA21000258-2	RP1065-10ug	10 ug	Sample	$99		Add to Cart
BHA21000258-3	RP1065-Biotin	100 ug	Biotin	$570		Add to Cart
BHA21000258-4	RP1065-Cy3	100 ug	Cy3	$570		Add to Cart
BHA21000258-5	RP1065-Dylight488	100 ug	Dylight488	$570		Add to Cart
BHA21000258-6	RP1065-Dylight550	100 ug	Dylight550	$570		Add to Cart
BHA21000258-7	RP1065-Dylight594	100 ug	Dylight594	$570		Add to Cart
BHA21000258-8	RP1065-FITC	100 ug	FITC	$570		Add to Cart
BHA21000258-9	RP1065-HRP	100 ug	HRP	$570		Add to Cart
BHA21000258-10	RP1065-APC	100 ug	APC	$670		Add to Cart
BHA21000258-11	RP1065-PE	100 ug	PE	$670		Add to Cart
BHA21000258-12	RP1065-iFluor647	100 ug	iFluor647	$670		Add to Cart
BHA21000258-13	RP1065-carrier-free	100 ug	carrier-free	$370		Add to Cart

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