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Home / Primary Antibodies / Polyclonal Antibodies

Anti-DR4/TNFRSF10A Antibody Picoband®

SKU : BHA21007209

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Mfr.No.	PA1975, PA1975-10ug, PA1975-Biotin, PA1975-Cy3, PA1975-Dylight488, PA1975-Dylight550, PA1975-Dylight594, PA1975-FITC, PA1975-HRP, PA1975-APC, PA1975-PE, PA1975-iFluor647, PA1975-carrier-free
Alternative Names	Tumor necrosis factor receptor superfamily member 10A
Background	TNFRSF10A (Tumor Necrosis Factor Receptor Subfamily Member 10A), also known as APO2, DR4 or TRAILR1, is a protein that in humans is encoded by the TNFRSF10A gene. The protein encoded by this gene is a member of the TNF-receptor superfamily. By analysis of radiation hybrids, Marsters et al. (1997) mapped the DR4 gene to 8p21. The TRAIL receptor DR5, and 2 decoy receptors for TRAIL, DCR1, and DCR2, are located in the same region, suggesting that these receptors arose from recent gene duplication events. Pan et al. (1997) found that, as with FAS, TNFR1, and DR3, overexpression of DR4 induced apoptosis. However, unlike the other 3 death receptors, DR4 did not use FADD to transmit the death signal, suggesting the use of distinct proximal signaling machinery.
Clonality	Polyclonal
Cross Reactivity	No cross-reactivity with other proteins
Description	Boster Bio Anti-DR4/TNFRSF10A Antibody catalog # PA1975. Tested in WB applications. This antibody reacts with Human. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Weste blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
Function	Receptor for the cytotoxic ligand TNFSF10/TRAIL. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade
Host	Rabbit
Immunogen Region	A synthetic peptide corresponding to a sequence at the N-terminus of human DR4.
Isotype	Rabbit IgG
Molecular Weight	150 kDa
Reactivity	Human
Reconstitution	Add 0.2ml of distilled water will yield a concentration of 500ug/ml.
Specificity	No cross reactivity with other proteins.
Synonyms	Tumor necrosis factor receptor superfamily member 10A;Death receptor 4;TNF-related apoptosis-inducing ligand receptor 1;TRAIL receptor 1;TRAIL-R1;CD261;TNFRSF10A;APO2, DR4, TRAILR1;
Tissue Specificity	Widely expressed. High levels are found in spleen, peripheral blood leukocytes, small intestine and thymus, but also in K-562 erythroleukemia cells, MCF-7 breast carcinoma cells and activated T-cells.
Note	Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3.

Uniprot	O00220
Gene Name	TNFRSF10A
Sequence	Contains 1 death domain.
Subcellular Location	Membrane; Single-pass type I membrane protein.

Conjugates	Biotin, Cy3, Dylight488, Dylight550, Dylight594, FITC, HRP, APC, PE, iFluor647, carrier-free

Concentration	Adding 0.2 ml of distilled water will yield a concentration of 500 ug/ml.
Form	Lyophilized
Purification	Immunogen affinity purified.
Storage	Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Applications	WB
Description	Weste blot, 0.1-0.5ug/ml, Human<br>

Reference	1. Marsters, S. A., Sheridan, J. P., Pitti, R. M., Huang, A., Skubatch, M., Baldwin, D., Yuan, J., Guey, A., Goddard, A. D., Godowski, P., Ashkenazi, A. A novel receptor for Apo2L/TRAIL contains a truncated death domain. Curr. Biol. 7: 1003-1006, 1997. <br /><br />2. Pan, G., O'Rourke, K., Chinnaiyan, A. M., Gentz, R., Ebner, R., Ni, J., Dixit, V. M. The receptor for the cytotoxic ligand TRAIL. Science 276: 111-113, 1997.<br /><br /><br /><br />

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Combination SKU	Supplier No.	Conjugation	Size	Your price	Quantity
BHA21007209-1	PA1975	-	100 ug	$370		Add to Cart
BHA21007209-2	PA1975-10ug	Sample	10 ug	$99		Add to Cart
BHA21007209-3	PA1975-Biotin	Biotin	100 ug	$570		Add to Cart
BHA21007209-4	PA1975-Cy3	Cy3	100 ug	$570		Add to Cart
BHA21007209-5	PA1975-Dylight488	Dylight488	100 ug	$570		Add to Cart
BHA21007209-6	PA1975-Dylight550	Dylight550	100 ug	$570		Add to Cart
BHA21007209-7	PA1975-Dylight594	Dylight594	100 ug	$570		Add to Cart
BHA21007209-8	PA1975-FITC	FITC	100 ug	$570		Add to Cart
BHA21007209-9	PA1975-HRP	HRP	100 ug	$570		Add to Cart
BHA21007209-10	PA1975-APC	APC	100 ug	$670		Add to Cart
BHA21007209-11	PA1975-PE	PE	100 ug	$670		Add to Cart
BHA21007209-12	PA1975-iFluor647	iFluor647	100 ug	$670		Add to Cart
BHA21007209-13	PA1975-carrier-free	carrier-free	100 ug	$370		Add to Cart

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