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Home / Primary Antibodies / Polyclonal Antibodies

Anti-DR3/TNFRSF25 Antibody Picoband®

SKU : BHA21007229

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Mfr.No.	PA2004, PA2004-10ug, PA2004-Biotin, PA2004-Cy3, PA2004-Dylight488, PA2004-Dylight550, PA2004-Dylight594, PA2004-FITC, PA2004-HRP, PA2004-APC, PA2004-PE, PA2004-iFluor647, PA2004-carrier-free
Alternative Names	Tumor necrosis factor receptor superfamily member 25
Background	TNFRSF25 (Tumor Necrosis Factor Receptor Superfamily Member 25), also known as LARD, APO3, DR3 or TNFR25, is a protein that in humans is encoded by the TNFRSF25 gene. Members of the mammalian tumor necrosis factor receptor (TNFR) family are cell-surface proteins that interact with a corresponding TNF-related ligand family. By fluorescence in situ hybridization, Marsters et al. (1996) mapped the Apo3 gene to 1p36.3. Marsters et al. (1996) showed that ectopic expression of Apo3 in mammalian cells triggered apoptosis and activated the transcription factor NF-kappa-B. They suggested that, like TNFR1, Apo3 may regulate distinct signaling pathways in different cellular contexts.
Clonality	Polyclonal
Cross Reactivity	No cross-reactivity with other proteins
Description	Boster Bio Anti-DR3/TNFRSF25 Antibody catalog # PA2004. Tested in WB applications. This antibody reacts with Human. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Weste blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
Function	Receptor for TNFSF12/APO3L/TWEAK. Interacts ly with the adapter TRADD. Mediates activation of NF-kappa-B and induces apoptosis. May play a role in regulating lymphocyte homeostasis.
Host	Rabbit
Immunogen Region	A synthetic peptide corresponding to a sequence at the N-terminus of human DR3.
Isotype	Rabbit IgG
Molecular Weight	59 kDa
Reactivity	Human
Reconstitution	Add 0.2ml of distilled water will yield a concentration of 500ug/ml.
Specificity	No cross reactivity with other proteins.
Synonyms	Tumor necrosis factor receptor superfamily member 25;Apo-3;Apoptosis-inducing receptor AIR;Apoptosis-mediating receptor DR3;Apoptosis-mediating receptor TRAMP;Death receptor 3;Lymphocyte-associated receptor of death;LARD;Protein WSL;Protein WSL-1;TNFRSF25;APO3, DDR3, DR3, TNFRSF12, WSL, WSL1;UNQ455/PRO779;
Tissue Specificity	Abundantly expressed in thymocytes and lymphocytes. Detected in lymphocyte-rich tissues such as thymus, colon, intestine, and spleen. Also found in the prostate.
Note	Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3.

Uniprot	Q93038
Gene Name	TNFRSF25
Sequence	Contains 1 death domain.
Subcellular Location	Isoform 1: Cell membrane; Single-pass type I membrane protein.

Conjugates	Biotin, Cy3, Dylight488, Dylight550, Dylight594, FITC, HRP, APC, PE, iFluor647, carrier-free

Concentration	Adding 0.2 ml of distilled water will yield a concentration of 500 ug/ml.
Form	Lyophilized
Purification	Immunogen affinity purified.
Storage	Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Applications	WB
Description	Weste blot, 0.1-0.5ug/ml, Human<br>

Reference	1. Borysenko, C. W., Furey, W. F., Blair, H. C. Comparative modeling of TNFRSF25 (DR3) predicts receptor destabilization by a mutation linked to rheumatoid arthritis. Biochem. Biophys. Res. Commun. 328: 794-799, 2005.<br /><br />2. Fang, L., Adkins, B., Deyev, V., Podack, E. R. Essential role of TNF receptor superfamily 25 (TNFRSF25) in the development of allergic lung inflammation. J. Exp. Med. 205: 1037-1048, 2008.<br /><br />3. Marsters, S. A., Sheridan, J. P., Donahue, C. J., Pitti, R. M., Gray, C. L., Goddard, A. D., Bauer, K. D., Ashkenazi, A. Apo-3, a new member of the tumor necrosis factor receptor family, contains a death domain and activates apoptosis and NF-kappa-B. Curr. Biol. 6: 1669-1676, 1996.<br /><br />

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Combination SKU	Supplier No.	Conjugation	Size	Your price	Quantity
BHA21007229-1	PA2004	-	100 ug	$370		Add to Cart
BHA21007229-2	PA2004-10ug	Sample	10 ug	$99		Add to Cart
BHA21007229-3	PA2004-Biotin	Biotin	100 ug	$570		Add to Cart
BHA21007229-4	PA2004-Cy3	Cy3	100 ug	$570		Add to Cart
BHA21007229-5	PA2004-Dylight488	Dylight488	100 ug	$570		Add to Cart
BHA21007229-6	PA2004-Dylight550	Dylight550	100 ug	$570		Add to Cart
BHA21007229-7	PA2004-Dylight594	Dylight594	100 ug	$570		Add to Cart
BHA21007229-8	PA2004-FITC	FITC	100 ug	$570		Add to Cart
BHA21007229-9	PA2004-HRP	HRP	100 ug	$570		Add to Cart
BHA21007229-10	PA2004-APC	APC	100 ug	$670		Add to Cart
BHA21007229-11	PA2004-PE	PE	100 ug	$670		Add to Cart
BHA21007229-12	PA2004-iFluor647	iFluor647	100 ug	$670		Add to Cart
BHA21007229-13	PA2004-carrier-free	carrier-free	100 ug	$370		Add to Cart

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