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Home / Primary Antibodies / Polyclonal Antibodies

Anti-DLGAP1 Antibody Picoband®

SKU : BHA21003338

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Mfr.No.	A08230-2, A08230-2-10ug, A08230-2-Biotin, A08230-2-Cy3, A08230-2-Dylight488, A08230-2-Dylight550, A08230-2-Dylight594, A08230-2-FITC, A08230-2-HRP, A08230-2-APC, A08230-2-PE, A08230-2-iFluor647, A08230-2-carrier-free
Alternative Names	leucine rich repeat containing 32
Background	Disks large-associated protein 1 (DAP-1), also known as guanylate kinase-associated protein (GKAP), is a protein that in humans is encoded by the DLGAP1 gene. The neurotransmitter glutamate facilitates neuronal signalling at excitatory synapses. Glutamate is released from the presynaptic membrane into the synaptic cleft. Across the synaptic cleft glutamate binds to both ion channels and metabotropic glutamate receptors at the postsynapse, which expedite downstream signalling in the neuron. The postsynaptic density, a highly specialized matrix, which is attached to the postsynaptic membrane, controls this downstream signalling. The postsynaptic density also resets the synapse after each synaptic firing. It is composed of numerous proteins including a family of Discs large associated protein 1, 2, 3 and 4 (DLGAP1-4) that act as scaffold proteins in the postsynaptic density. They link the glutamate receptors in the postsynaptic membrane to other glutamate receptors, to signalling proteins and to components of the cytoskeleton. With the central localisation in the postsynapse, the DLGAP family seems to play a vital role in synaptic scaling by regulating the tuover of both ionotropic and metabotropic glutamate receptors in response to synaptic activity. DLGAP family has been ly linked to a variety of psychological and neurological disorders.
Clonality	Polyclonal
Cross Reactivity	No cross-reactivity with other proteins.
Description	Boster Bio Anti-DLGAP1 Antibody Picoband® catalog # A08230-2. Tested in ELISA, Flow Cytometry, IF, IHC, ICC, WB applications. This antibody reacts with Human, Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Weste blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
Function	Key regulator of transforming growth factor beta (TGFB1, TGFB2 and TGFB3) that controls TGF-beta activation by maintaining it in a latent state during storage in extracellular space. Associates specifically via disulfide bonds with the Latency-associated
Host	Rabbit
Immunogen Region	E.coli-derived human DLGAP1 recombinant protein (Position: D17-Q319).
Isotype	Rabbit IgG
Molecular Weight	130 kDa
Reactivity	Human, Mouse, Rat
Reconstitution	Add 0.2ml of distilled water will yield a concentration of 500ug/ml.
Synonyms	Transforming growth factor beta activator LRRC32; Garpin; Glycoprotein A repetitions predominant; GARP; Leucine-rich repeat-containing protein 32; LRRC32; D11S833E
Tissue Specificity	Heart, placenta, skeletal muscle, kidney, lung and pancreas.
Note	Each vial contains 4mg Trehalose, 0.9mg NaCl, 0.2mg Na2HPO4.

Uniprot	O14490
Gene Id	9229
Gene Name	DLGAP1
Subcellular Location	Cell membrane. Single-pass type I membrane protein. Cell surface.

Conjugates	Biotin, Cy3, Dylight488, Dylight550, Dylight594, FITC, HRP, APC, PE, iFluor647, carrier-free

Concentration	Adding 0.2 ml of distilled water will yield a concentration of 500 ug/ml.
Form	Lyophilized
Purification	Immunogen affinity purified.
Storage	Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Applications	WB, IHC, Flow Cytometry, ICC, IF, ELISA
Description	Weste blot, 0.25-0.5ug/ml, Mouse, Rat<br> Immunohistochemistry (Paraffin-embedded Section), 2-5ug/ml, Human, Rat<br> Immunocytochemistry/Immunofluorescence, 5ug/ml, Human<br> Flow Cytometry (Fixed), 1-3ug/1x10<sup>6</sup> cells, Human<br> ELISA, 0.1-0.5ug/ml, -<br>

Reference	1. Gross, M. B. Personal Communication. Baltimore, Md. 5/20/2014.<br /><br />2. Kim, E., Naisbitt, S., Hsueh, Y.-P., Rao, A., Rothschild, A., Craig, A. M., Sheng, M. GKAP, a novel synaptic protein that interacts with the guanylate kinase-like domain of the PSD-95/SAP90 family of channel clustering molecules. J. Cell Biol. 136: 669-678, 1997. <br /><br />3. Satoh, K., Yanai, H., Senda, T., Kohu, K., Nakamura, T., Okumura, N., Matsumine, A., Kobayashi, S., Toyoshima, K., Akiyama, T. DAP-1, a novel protein that interacts with the guanylate kinase-like domains of hDLG and PSD-95. Genes Cells 2: 415-424, 1997.

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Combination SKU	Supplier No.	Conjugation	Size	Your price	Quantity
BHA21003338-1	A08230-2	-	100 ug	$370		Add to Cart
BHA21003338-2	A08230-2-10ug	Sample	10 ug	$99		Add to Cart
BHA21003338-3	A08230-2-Biotin	Biotin	100 ug	$570		Add to Cart
BHA21003338-4	A08230-2-Cy3	Cy3	100 ug	$570		Add to Cart
BHA21003338-5	A08230-2-Dylight488	Dylight488	100 ug	$570		Add to Cart
BHA21003338-6	A08230-2-Dylight550	Dylight550	100 ug	$570		Add to Cart
BHA21003338-7	A08230-2-Dylight594	Dylight594	100 ug	$570		Add to Cart
BHA21003338-8	A08230-2-FITC	FITC	100 ug	$570		Add to Cart
BHA21003338-9	A08230-2-HRP	HRP	100 ug	$570		Add to Cart
BHA21003338-10	A08230-2-APC	APC	100 ug	$670		Add to Cart
BHA21003338-11	A08230-2-PE	PE	100 ug	$670		Add to Cart
BHA21003338-12	A08230-2-iFluor647	iFluor647	100 ug	$670		Add to Cart
BHA21003338-13	A08230-2-carrier-free	carrier-free	100 ug	$370		Add to Cart

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