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Home / Primary Antibodies / Polyclonal Antibodies

Anti-DKK1 Antibody Picoband®

SKU : BHA21001909

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Mfr.No.	A00632, A00632-10ug, A00632-Biotin, A00632-Cy3, A00632-Dylight488, A00632-Dylight550, A00632-Dylight594, A00632-FITC, A00632-HRP, A00632-APC, A00632-PE, A00632-iFluor647, A00632-carrier-free
Alternative Names	dickkopf 1 homolog (Xenopus laevis)
Background	DKK1, Dickkopf-related protein 1, is a protein that in humans is encoded by the DKK1 gene. This gene encodes a protein that is a member of the dickkopf family. By genomic sequence analysis, determined that the DKK1 gene contains 4 exons. The DKK1 gene is mapped to 10q11.2 using FISH. It is a secreted protein with two cysteine rich regions and is involved in embryonic development through its inhibition of the WNT signaling pathway. Elevated levels of DKK1 in bone marrow plasma and peripheral blood is associated with the presence of osteolytic bone lesions in patients with multiple myeloma.
Clonality	Polyclonal
Cross Reactivity	No cross-reactivity with other proteins.
Description	Boster Bio Anti-DKK1 Antibody Picoband® catalog # A00632. Tested in WB applications. This antibody reacts with Human, Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Weste blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
Function	Antagonizes canonical Wnt signaling by inhibiting LRP5/6 interaction with Wnt and by forming a teary complex with the transmembrane protein KREMEN that promotes intealization of LRP5/6 (PubMed:22000856). DKKs play an important role in vertebrate devel
Host	Rabbit
Immunogen Region	E. coli-derived human DKK1 recombinant protein (Position: T32-H266).
Isotype	Rabbit IgG
Molecular Weight	38 kDa
Reactivity	Human, Mouse, Rat
Reconstitution	Add 0.2ml of distilled water will yield a concentration of 500ug/ml.
Specificity	No cross reactivity with other proteins.
Synonyms	Dickkopf-related protein 1; Dickkopf-1; Dkk-1; hDkk-1; SK; DKK1; UNQ492/PRO1008
Tissue Specificity	Placenta.
Note	Each vial contains 4mg Trehalose, 0.9mg NaCl, 0.2mg Na<sub>2</sub>HPO<sub>4</sub>, 0.05mg NaN<sub>3</sub>.

Uniprot	O94907
Gene Id	22943
Gene Name	DKK1
Subcellular Location	Secreted.

Conjugates	Biotin, Cy3, Dylight488, Dylight550, Dylight594, FITC, HRP, APC, PE, iFluor647, carrier-free

Concentration	Adding 0.2 ml of distilled water will yield a concentration of 500 ug/ml.
Form	Lyophilized
Purification	Immunogen affinity purified.
Storage	Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Applications	WB
Description	Weste blot, 0.1-0.5ug/ml<br>

Reference	1. Fedi, P., Bafico, A., Soria, A. N., Burgess, W. H., Miki, T., Bottaro, D. P., Kraus, M. H., Aaronson, S. A.Isolation and biochemical characterization of the human Dkk-1 homologue, a novel inhibitor of mammalian Wnt signaling.J. Biol. Chem. 274: 19465-19472, 1999.<br /><br />2. Roessler, E., Du, Y., Glinka, A., Dutra, A., Niehrs, C., Muenke, M.The genomic structure, chromosome location, and analysis of the human DKK1 head inducer gene as a candidate for holoprosencephaly. Cytogenet. Cell Genet. 89: 220-224, 2000.<br /><br />3. Tian, E., Zhan, F., Walker, R., Rasmussen, E., Ma, Y., Barlogie, B., Shaughnessy, J. D., Jr.The role of Wnt-signaling antagonist DKK1 in the development of osteolytic lesions in multiple myeloma.New Eng. J. Med. 349: 2483-2494, 2003.

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Combination SKU	Supplier No.	Size	Conjugation	Your price	Quantity
BHA21001909-1	A00632	100 ug	-	$370		Add to Cart
BHA21001909-2	A00632-10ug	10 ug	Sample	$99		Add to Cart
BHA21001909-3	A00632-Biotin	100 ug	Biotin	$570		Add to Cart
BHA21001909-4	A00632-Cy3	100 ug	Cy3	$570		Add to Cart
BHA21001909-5	A00632-Dylight488	100 ug	Dylight488	$570		Add to Cart
BHA21001909-6	A00632-Dylight550	100 ug	Dylight550	$570		Add to Cart
BHA21001909-7	A00632-Dylight594	100 ug	Dylight594	$570		Add to Cart
BHA21001909-8	A00632-FITC	100 ug	FITC	$570		Add to Cart
BHA21001909-9	A00632-HRP	100 ug	HRP	$570		Add to Cart
BHA21001909-10	A00632-APC	100 ug	APC	$670		Add to Cart
BHA21001909-11	A00632-PE	100 ug	PE	$670		Add to Cart
BHA21001909-12	A00632-iFluor647	100 ug	iFluor647	$670		Add to Cart
BHA21001909-13	A00632-carrier-free	100 ug	carrier-free	$370		Add to Cart

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