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Home / Primary Antibodies / Polyclonal Antibodies

Anti-DISC1 Antibody Picoband®

SKU : BHA21007245

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Mfr.No.	PA2023, PA2023-10ug, PA2023-Biotin, PA2023-Cy3, PA2023-Dylight488, PA2023-Dylight550, PA2023-Dylight594, PA2023-FITC, PA2023-HRP, PA2023-APC, PA2023-PE, PA2023-iFluor647, PA2023-carrier-free
Alternative Names	Disrupted in schizophrenia 1 protein
Background	DISC1 (Disrupted in Schizophrenia 1), is a protein that is encoded by the DISC1 gene in humans. Ma et al. (2002) determined that the mouse Disc1 gene maps to chromosome 8 in a region with homology of synteny to human chromosome 1q42. Ozeki et al. (2003) demonstrated that rodent Disc1 expression displayed pronounced developmental regulation, with the highest levels in late embryonic life during development of the cerebral cortex. Millar et al. (2005) showed that DISC1 interacts with the UCR2 domain of phosphodiesterase-4B, implicated in susceptibility to schizophrenia, and that elevation of cellular cAMP leads to dissociation of PDE4B from DISC1 and in increase in PDE4B activity.
Clonality	Polyclonal
Cross Reactivity	No cross-reactivity with other proteins
Description	Boster Bio Anti-DISC1 Antibody catalog # PA2023. Tested in WB applications. This antibody reacts with Human. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Weste blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
Function	Involved in the regulation of multiple aspects of embryonic and adult neurogenesis. Required for neural progenitor proliferation in the ventrical/subventrical zone during embryonic brain development and in the adult dentate gyrus of the hippocampus. Parti
Host	Rabbit
Immunogen Region	A synthetic peptide corresponding to a sequence at the N-terminus of human DISC1.
Isotype	Rabbit IgG
Molecular Weight	22 kDa
Reactivity	Human
Reconstitution	Add 0.2ml of distilled water will yield a concentration of 500ug/ml.
Specificity	No cross reactivity with other proteins.
Synonyms	Disrupted in schizophrenia 1 protein;DISC1;KIAA0457;
Tissue Specificity	Ubiquitous. Highly expressed in the dentate gyrus of the hippocampus. Also expressed in the temporal and parahippocampal cortices and cells of the white matter. .
Note	Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3.

Uniprot	Q9NRI5
Gene Name	DISC1
Sequence	Belongs to the G-protein coupled receptor 1 family.
Subcellular Location	Cytoplasm. Cytoplasm, cytoskeleton. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cell junction, synapse, postsynaptic cell membrane, postsynaptic density . Colocalizes with NDEL1 in the perinuclear region and the centrosome (By similarity). Localizes to punctate cytoplasmic foci which overlap in part with mitochondria. Colocalizes with PCNT at the centrosome. .

Conjugates	Biotin, Cy3, Dylight488, Dylight550, Dylight594, FITC, HRP, APC, PE, iFluor647, carrier-free

Concentration	Adding 0.2 ml of distilled water will yield a concentration of 500 ug/ml.
Form	Lyophilized
Purification	Immunogen affinity purified.
Storage	Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Applications	WB
Description	Weste blot, 0.1-0.5ug/ml, Human<br>

Reference	1. Ma, L., Liu, Y., Ky, B., Shughrue, P. J., Austin, C. P., Morris, J. A. Cloning and characterization of Disc1, the mouse ortholog of DISC1 (disrupted-in-schizophrenia 1). Genomics 80: 662-672, 2002. <br /><br />2. Millar, J. K., Pickard, B. S., Mackie, S., James, R., Christie, S., Buchanan, S. R., Malloy, M. P., Chubb, J. E., Huston, E., Baillie, G. S., Thomson, P. A., Hill, E. V., Brandon, N. J., Rain, J.-C., Camargo, L. M., Whiting, P. J., Houslay, M. D., Blackwood, D. H. R., Muir, W. J., Porteous, D. J. DISC1 and PDE4B are interacting genetic factors in schizophrenia that regulate cAMP signaling. Science 310: 1187-1191, 2005.<br /><br />3. Ozeki, Y., Tomoda, T., Kleiderlein, J., Kamiya, A., Bord, L., Fujii, K., Okawa, M., Yamada, N., Hatten, M. E., Snyder, S. H., Ross, C. A., Sawa, A. Disrupted-in-schizophrenia-1 (DISC-1): mutant truncation prevents binding to NudE-like (NUDEL) and inhibits neurite outgrowth. Proc. Nat. Acad. Sci. 100: 289-294, 2003.<br /><br />

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Combination SKU	Supplier No.	Conjugation	Size	Your price	Quantity
BHA21007245-1	PA2023	-	100 ug	$370		Add to Cart
BHA21007245-2	PA2023-10ug	Sample	10 ug	$99		Add to Cart
BHA21007245-3	PA2023-Biotin	Biotin	100 ug	$570		Add to Cart
BHA21007245-4	PA2023-Cy3	Cy3	100 ug	$570		Add to Cart
BHA21007245-5	PA2023-Dylight488	Dylight488	100 ug	$570		Add to Cart
BHA21007245-6	PA2023-Dylight550	Dylight550	100 ug	$570		Add to Cart
BHA21007245-7	PA2023-Dylight594	Dylight594	100 ug	$570		Add to Cart
BHA21007245-8	PA2023-FITC	FITC	100 ug	$570		Add to Cart
BHA21007245-9	PA2023-HRP	HRP	100 ug	$570		Add to Cart
BHA21007245-10	PA2023-APC	APC	100 ug	$670		Add to Cart
BHA21007245-11	PA2023-PE	PE	100 ug	$670		Add to Cart
BHA21007245-12	PA2023-iFluor647	iFluor647	100 ug	$670		Add to Cart
BHA21007245-13	PA2023-carrier-free	carrier-free	100 ug	$370		Add to Cart

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