Anti-Desmoglein-3 Antibody BHA10200843

Mfr.No.	1830-MSM5-P1ABX
Alternative Names	130kDa pemphigus vulgaris antigen (PVA) ; Balding (Bal) ; Cadherin family member 6 (CDHF6) ; Desmoglein-3 (DSG3)
Categories	Primary Antibodies
Cellular Localization	Cell Surface
Chromosome Location	18q12.1
Clonality	Monoclonal
Description	Recognizes a protein of 130kDa, identified as Desmoglein-3 (DSG3). This MAb is highly specific to Desmoglein-3 and does not cross-react with other members of the Desmoglein-family. DSG3 is a calcium-binding transmembrane glycoprotein component of desmosomes in vertebrate epithelial cells. Research has shown that DSG3 has a very high sensitivity (>80%) and specificity (100%) in recognizing squamous cell carcinoma (SqCC). Therefore, DSG3 is considered a very important marker for lung SqCC and can be a useful ancillary marker to separate SqCC from other subtypes of lung cancer. Moreover, studies have shown that DSG3 expression in lung SqCC may indicate a poor prognosis.
Host	Mouse
Immunogen	Recombinant human DSG3 extracellular protein fragment (exact sequence is proprietary)
Isotype	IgG1 Kappa
Positive Control	A431 cells. Skin or Lung squamous cell carcinoma.
Reactivity	Human
Recombinant	FALSE
Regulatory	RUO

Swissprot	P32926
Uniprot	1925
Gene Id	1830

Buffer	200μg/ml of Ab purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.
Concentration	1.0mg/ml
Description	There are no warranties, expressed or implied, which extend beyond this description. Company is not liable for any personal injury or economic loss resulting from this product.
Purity	Purified Ab WITHOUT BSA and Azide at 1.0mg/ml

Applications

FACS, IF, WB, IHC-F

Description

(Staining of formalin-fixed tissues requires boiling tissue sections in 10mM Citrate buffer, pH 6.0, for 10-20 min followed by cooling at RT for 20 minutes),Optimal dilution for a specific application should be determined., FACS ; IF ; WB ; IHC-F

Dilution

FACS	0.5-1μg/million cells
IF	1-2μg/ml
WB	0.5-1.0μg/ml
IHC-F	1-2μg/ml for 30 minutes at RT

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SKU	Supplier No.	Size	Your price	Quantity
BHA10200843	1830-MSM5-P1ABX	100µg	$393.20		Add to Cart

Anti-Desmoglein-3 Antibody BHA10200843

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