Anti-Desmocollin-2/3 Antibody BHA10200756

Mfr.No.	1824-MSM1-P1ABX
Alternative Names	ARVD11 ; Cadherin family member 2 ; CDHF2 ; Desmocollin-2 ; Desmocollin-3 ; Desmosomal glycoprotein II and III ; Desmosomal glycoprotein II ; Desmosomal glycoprotein III ; DG2 ; DGII/III
Categories	Primary Antibodies
Cellular Localization	Cell Surface
Chromosome Location	18q12.1
Clonality	Monoclonal
Description	Desmosomes are intercellular adhering junctions that represent cell surface attachment sites for intermediate filament. The desmosome is subdivided into two regions. The plaque region lies adjacent to the plasma, and is believed to contain molecules that attach the intermediate filament cytoskeleton to the desmosome. The core region is composed of transmembrane glycoproteins that are thought to mediate cell-cell adhesion. Desmogleins and desmocollins are the main desmosomal transmembrane proteins. These desmosomal glycoproteins belong to the members of the cadherin family of adhesion molecules. Three different isoforms of both desmogleins and desmocollins have been identified, named as desmoglein 1-3 and desmocollins. Desmosomal cadherins showed differentiation-specific expression in the human epidermis, although the functional significance of this differential expression is not fully understood. Desmocollin-1 can be found in the upper layers. The expression of desmocollin-2 varies in the basal and suprabasal layers. And desmocollin-3 is expressed more evenly throughout the suprabasal layers.
Host	Mouse
Immunogen	Human desmocollin-2 extracellular domain (exact sequence is proprietary)
Isotype	IgG1 Kappa
Positive Control	HeLa cells. Skin
Reactivity	Human, Mouse, Rat
Recombinant	FALSE
Regulatory	RUO

Swissprot	Q02487
Uniprot	95612
Gene Id	1824

Buffer	200μg/ml of Ab purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.
Concentration	1.0mg/ml
Description	There are no warranties, expressed or implied, which extend beyond this description. Company is not liable for any personal injury or economic loss resulting from this product.
Purity	Purified Ab WITHOUT BSA and Azide at 1.0mg/ml

Applications

FACS, IF, WB, IHC-F

Description

(Staining of formalin-fixed tissues requires boiling tissue sections in 10mM Tris with 1mM EDTA, pH 9.0, for 10-20 min followed by cooling at RT for 20 minutes),Optimal dilution for a specific application should be determined., FACS ; IF ; WB ; IHC-F

Dilution

FACS	0.5-1μg/million cells
IF	1-2μg/ml
WB	0.5-1.0μg/ml
IHC-F	1-2μg/ml for 30 minutes at RT

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SKU	Supplier No.	Size	Your price	Quantity
BHA10200756	1824-MSM1-P1ABX	100µg	$393.20		Add to Cart

Anti-Desmocollin-2/3 Antibody BHA10200756

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