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Home / Primary Antibodies / Monoclonal Antibodies

Anti-Cytokeratin 8 KRT8 Antibody Picoband® (monoclonal, 3G9)

SKU : BHA21002119

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Mfr.No.	M01421-3, M01421-3-10ug, M01421-3-Biotin, M01421-3-Cy3, M01421-3-Dylight488, M01421-3-Dylight550, M01421-3-Dylight594, M01421-3-FITC, M01421-3-HRP, M01421-3-APC, M01421-3-PE, M01421-3-iFluor647, M01421-3-carrier-free
Alternative Names	keratin 8
Background	Keratin, type II cytoskeletal 8, also known as cytokeratin-8 (CK-8) or keratin-8 (K8) is a keratin protein that is encoded in humans by the KRT8 gene. This gene is a member of the type II keratin family clustered on the long arm of chromosome 12. Type I and type II keratins heteropolymerize to form intermediate-sized filaments in the cytoplasm of epithelial cells. The product of this gene typically dimerizes with keratin 18 to form an intermediate filament in simple single-layered epithelial cells. This protein plays a role in maintaining cellular structural integrity and also functions in signal transduction and cellular differentiation. Mutations in this gene cause cryptogenic cirrhosis. Alteatively spliced transcript variants have been found for this gene.
Clonality	Monoclonal
Cross Reactivity	No cross-reactivity with other proteins.
Description	Boster Bio Anti-Cytokeratin 8 KRT8 Antibody Picoband® (monoclonal, 3G9) catalog # M01421-3. Tested in Flow Cytometry, IF, IHC, IHC-F, ICC, WB applications. This antibody reacts with Human, Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Weste blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
Function	Together with KRT19, helps to link the contractile apparatus to dystrophin at the costameres of striated muscle.
Host	Mouse
Immunogen Region	E.coli-derived human Cytokeratin 8 recombinant protein (Position: D107-K325). Human Cytokeratin 8 shares 95.4% and 94.5% amino acid (aa) sequence identity with mouse and rat Cytokeratin 8, respectively.
Isotype	Mouse IgG2b
Molecular Weight	54 kDa
Reactivity	Human, Mouse, Rat
Reconstitution	Add 0.2ml of distilled water will yield a concentration of 500ug/ml.
Specificity	No cross reactivity with other proteins.
Synonyms	Keratin, type II cytoskeletal 8; Cytokeratin-8; CK-8; K8; Type-II keratin Kb8; KRT8; CYK8
Tissue Specificity	Observed in muscle fibers accumulating in the costameres of myoplasm at the sarcolemma membrane in structures that contain dystrophin and spectrin. Expressed in gingival mucosa and hard palate of the oral cavity.
Note	Each vial contains 4mg Trehalose, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg NaN3.

Uniprot	P05787
Gene Id	3856
Gene Name	KRT8
Clone No	Clone: 3G9
Subcellular Location	Nucleoplasm. Nucleus matrix. Cytoplasm.

Conjugates	Biotin, Cy3, Dylight488, Dylight550, Dylight594, FITC, HRP, APC, PE, iFluor647, carrier-free

Concentration	Adding 0.2 ml of distilled water will yield a concentration of 500 ug/ml.
Form	Lyophilized
Purification	Immunogen affinity purified.
Storage	Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Applications	Flow Cytometry, IF, IHC, IHC-F, ICC, WB
Description	Weste blot, 0.1-0.5ug/ml<br> Immunohistochemistry (Paraffin-embedded Section), 0.5-1ug/ml<br> Immunohistochemistry (Frozen Section), 0.5-1ug/ml<br> Immunofluorescence, 2ug/ml<br> Immunocytochemistry/Immunofluorescence, 2ug/ml<br> Flow Cytometry (Fixed), 1-3ug/1x10<sup>6</sup> cells

Reference	1.He, T.; Stepulak, A.; Holmstrom, T. H.; Omary, M. B.; Eriksson, J. E. : The intermediate filament protein kinase 8 is a novel cytoplasmic substrate for c-Jun N-terminal kinase. J. Biol. Chem. 277: 10767-10774, 2002.<br /><br />2.Krauss, S.; Franke, W. W. : Organization and sequence of the human gene encoding cytokeratin 8. Gene 86: 241-249, 1990. <br /><br />3.Yamamoto, R.; Kao, L.-C.; McKnight, C. E.; Strauss, J. F., III : Cloning and sequence of cDNA for human placental cytokeratin 8: regulation of the mRNA in trophoblastic cells by cAMP. Molec. Endocr. 4: 370-374, 1990.

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Combination SKU	Supplier No.	Conjugation	Size	Your price	Quantity
BHA21002119-1	M01421-3	-	100 ug	$370		Add to Cart
BHA21002119-2	M01421-3-10ug	Sample	10 ug	$99		Add to Cart
BHA21002119-3	M01421-3-Biotin	Biotin	100 ug	$570		Add to Cart
BHA21002119-4	M01421-3-Cy3	Cy3	100 ug	$570		Add to Cart
BHA21002119-5	M01421-3-Dylight488	Dylight488	100 ug	$570		Add to Cart
BHA21002119-6	M01421-3-Dylight550	Dylight550	100 ug	$570		Add to Cart
BHA21002119-7	M01421-3-Dylight594	Dylight594	100 ug	$570		Add to Cart
BHA21002119-8	M01421-3-FITC	FITC	100 ug	$570		Add to Cart
BHA21002119-9	M01421-3-HRP	HRP	100 ug	$570		Add to Cart
BHA21002119-10	M01421-3-APC	APC	100 ug	$670		Add to Cart
BHA21002119-11	M01421-3-PE	PE	100 ug	$670		Add to Cart
BHA21002119-12	M01421-3-iFluor647	iFluor647	100 ug	$670		Add to Cart
BHA21002119-13	M01421-3-carrier-free	carrier-free	100 ug	$370		Add to Cart

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