Cytokeratin 5 dimerizes with Cytokeratin 14 to form the cytoskeleton of basal epithelial cells, while Cytokeratin 6 multimerizes with Cytokeratin 16 and/or 17 in the tongue, oral epithelia and esophagus, hair follicles, and glandular epithelia. Anti-Cytokeratin 5 & 6 rarely stains lung adenocarcinoma, but will produce small foci or scattered staining patterns in these Cytokeratin 5 & 6(+) samples. Cytokeratin 5 & 6 staining is useful for identifying squamous cell carcinoma, and can be used to determine the malignancies of myoepithelial cells in the breast and prostate. Cytokeratin 5 & 6 also rarely stains carcinomas of the breast, colon, and prostate. A panel of antibodies against Cytokeratin 5 & 6, TTF-1, napsin A, p63, SOX2, DSC3, and desmoglein-3 is useful for differentiating lung squamous cell carcinoma from lung adenocarcinoma and large cell carcinoma.
Host
Mouse
Isotype
IgG1
Species
Human
Clone No
IHC556
Buffer
Tris Buffer pH7.6 with BSA, and sodium azide as preservative