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Home / Primary Antibodies / Monoclonal Antibodies

Anti-Cytokeratin 18 KRT18 Antibody Picoband®(monoclonal, 7I6)

SKU : BHA21002440

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Mfr.No.	M01357-4, M01357-4-10ug, M01357-4-Biotin, M01357-4-Cy3, M01357-4-Dylight488, M01357-4-Dylight550, M01357-4-Dylight594, M01357-4-FITC, M01357-4-HRP, M01357-4-APC, M01357-4-PE, M01357-4-iFluor647, M01357-4-carrier-free
Alternative Names	keratin 18
Background	Keratin 18, mapped to 12q13.13, is a type I cytokeratin. It is, together with its filament partner keratin 8, perhaps the most commonly found products of the intermediate filament gene family. They are expressed in single layer epithelial tissues of the body. Mutations in this gene have been linked to cryptogenic cirrhosis. Two transcript variants encoding the same protein have been found for this gene.
Clonality	Monoclonal
Cross Reactivity	No cross-reactivity with other proteins.
Description	Boster Bio Anti-Cytokeratin 18 KRT18 Antibody Picoband® (monoclonal, 7I6) catalog # M01357-4. Tested in Flow Cytometry, IF, IHC, IHC-F, ICC, WB applications. This antibody reacts with Human. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Weste blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
Function	Involved in the uptake of thrombin-antithrombin complexes by hepatic cells. When phosphorylated, plays a role in filament reorganization. Involved in the delivery of mutated CFTR to the plasma membrane. Together with KRT8, is involved in interleukin-6 (IL
Host	Mouse
Immunogen Region	E.coli-derived human Cytokeratin 18 recombinant protein (Position: E204-H430). Human Cytokeratin 18 shares 87.7% and 85.9% amino acid (aa) sequence identity with mouse and rat Cytokeratin 18, respectively.
Isotype	Mouse IgG1
Molecular Weight	48 kDa
Reactivity	Human
Reconstitution	Add 0.2ml of distilled water will yield a concentration of 500ug/ml.
Specificity	No cross reactivity with other proteins.
Synonyms	Keratin, type I cytoskeletal 18; Cell proliferation-inducing gene 46 protein; Cytokeratin-18; CK-18; Keratin-18; K18; KRT18; CYK18; PIG46
Tissue Specificity	Expressed in colon, placenta, liver and very weakly in exocervix. Increased expression observed in lymph nodes of breast carcinoma.
Note	Each vial contains 4mg Trehalose, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg NaN3.

Uniprot	P05783
Gene Id	3875
Gene Name	KRT18
Clone No	Clone: 7I6
Subcellular Location	Nucleolus. Perinuclear region.

Conjugates	Biotin, Cy3, Dylight488, Dylight550, Dylight594, FITC, HRP, APC, PE, iFluor647, carrier-free

Concentration	Adding 0.2 ml of distilled water will yield a concentration of 500 ug/ml.
Form	Lyophilized
Purification	Immunogen affinity purified.
Storage	Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Applications	Flow Cytometry, IF, IHC, IHC-F, ICC, WB
Description	Weste blot, 0.1-0.5ug/ml, Human<br> Immunohistochemistry (Paraffin-embedded Section), 0.5-1ug/ml, Human<br> Immunohistochemistry (Frozen Section), 0.5-1ug/ml, Human<br> Immunocytochemistry/Immunofluorescence, 2ug/ml, Human<br> Immunofluorescence, 2ug/ml, Human<br> Flow Cytometry (Fixed), 1-3ug/1x10<sup>6</sup> cells, Human<br>

Reference	1. "Entrez Gene: KRT18 keratin 18". <br /><br />2. Ku, N.-O., Wright, T. L., Terrault, N. A., Gish, R., Omary, M. B. Mutation of human keratin 18 in association with cryptogenic cirrhosis. J. Clin. Invest. 99: 19-23, 1997. <br /><br />3. Ku, N.-O., Darling, J. M., Krams, S. M., Esquivel, C. O., Keeffe, E. B., Sibley, R. K., Lee, Y. M., Wright, T. L., Omary, M. B. Keratin 8 and 18 mutations are risk factors for developing liver disease of multiple etiologies. Proc. Nat. Acad. Sci. 100: 6063-6068, 2003.<br /><br />

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Combination SKU	Supplier No.	Conjugation	Size	Your price	Quantity
BHA21002440-1	M01357-4	-	100 ug	$370		Add to Cart
BHA21002440-2	M01357-4-10ug	Sample	10 ug	$99		Add to Cart
BHA21002440-3	M01357-4-Biotin	Biotin	100 ug	$570		Add to Cart
BHA21002440-4	M01357-4-Cy3	Cy3	100 ug	$570		Add to Cart
BHA21002440-5	M01357-4-Dylight488	Dylight488	100 ug	$570		Add to Cart
BHA21002440-6	M01357-4-Dylight550	Dylight550	100 ug	$570		Add to Cart
BHA21002440-7	M01357-4-Dylight594	Dylight594	100 ug	$570		Add to Cart
BHA21002440-8	M01357-4-FITC	FITC	100 ug	$570		Add to Cart
BHA21002440-9	M01357-4-HRP	HRP	100 ug	$570		Add to Cart
BHA21002440-10	M01357-4-APC	APC	100 ug	$670		Add to Cart
BHA21002440-11	M01357-4-PE	PE	100 ug	$670		Add to Cart
BHA21002440-12	M01357-4-iFluor647	iFluor647	100 ug	$670		Add to Cart
BHA21002440-13	M01357-4-carrier-free	carrier-free	100 ug	$370		Add to Cart

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