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Home / Primary Antibodies / Polyclonal Antibodies

Anti-Cytochrome P450 Reductase/POR Antibody Picoband®

SKU : BHA21000634

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Mfr.No.	PB9736, PB9736-10ug, PB9736-Biotin, PB9736-Cy3, PB9736-Dylight488, PB9736-Dylight550, PB9736-Dylight594, PB9736-FITC, PB9736-HRP, PB9736-APC, PB9736-PE, PB9736-iFluor647, PB9736-carrier-free
Alternative Names	NADPH--cytochrome P450 reductase
Background	POR is a membrane-boundenzyme required for electron transfer from NADPH to cytochrome P450 in the endoplasmic reticulum of theeukaryotic cell. The gene encodes an endoplasmic reticulum membrane oxidoreductase with an FAD-binding domain and a flavodoxin-like domain. The protein binds two cofactors, FAD and FMN, which allow it to donate electrons ly from NADPH to all microsomal P450 enzymes. Mutations in this gene have been associated with various diseases, including apparent combined P450C17 and P450C21 deficiency, amenorrhea and disordered steroidogenesis, congenital adrenal hyperplasia and Antley-Bixler syndrome.
Clonality	Polyclonal
Cross Reactivity	No cross-reactivity with other proteins.
Description	Boster Bio Anti-Cytochrome P450 Reductase/POR Antibody Picoband® catalog # PB9736. Tested in Flow Cytometry, IHC, ICC, WB applications. This antibody reacts with Human, Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Weste blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
Function	This enzyme is required for electron transfer from NADP to cytochrome P450 in microsomes. It can also provide electron transfer to heme oxygenase and cytochrome B5.
Host	Rabbit
Immunogen Region	A synthetic peptide corresponding to a sequence at the C-terminus of human POR, different from the related mouse and rat sequences by five amino acids.
Isotype	Rabbit IgG
Molecular Weight	77 kDa
Reactivity	Human, Mouse, Rat
Reconstitution	Add 0.2ml of distilled water will yield a concentration of 500ug/ml.
Specificity	No cross reactivity with other proteins.
Synonyms	NADPH--cytochrome P450 reductase;CPR;P450R;1.6.2.4;POR;CYPOR;
Tissue Specificity	Appears to be expressed ubiquitously. The Tyr- 9 phosphorylated form is markedly increased in diseased tissue compared with normal tissue from lung, liver, colon and breast. .
Note	Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg NaN3.

Uniprot	P16435
Gene Id	5447
Gene Name	POR
Subcellular Location	Endoplasmic reticulum membrane; Peripheral membrane protein. Anchored to the ER membrane by its N- terminal hydrophobic region.

Conjugates	Biotin, Cy3, Dylight488, Dylight550, Dylight594, FITC, HRP, APC, PE, iFluor647, carrier-free

Concentration	Adding 0.2 ml of distilled water will yield a concentration of 500 ug/ml.
Form	Lyophilized
Purification	Immunogen affinity purified.
Storage	Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Applications	Flow Cytometry, IHC, ICC, WB
Description	Immunohistochemistry (Paraffin-embedded Section), 0.5-1ug/ml, Human, Mouse, Rat, By Heat Weste blot, 0.1-0.5ug/ml, Human, Mouse, Rat Immunohistochemistry (Frozen Section), 0.5-1ug/ml, Human Immunocytochemistry, 0.5-1ug/ml, Human Flow Cytometry (Fixed), 1-3ug/1x10⁶ cells, Human

Reference	1. Adachi, M., Asakura, Y., Matsuo, M., Yamamoto, T., Hanaki, K., Arlt, W. POR R457H is a global founder mutation causing Antley-Bixler syndrome with autosomal recessive trait. (Letter) Am. J. Med. Genet. 140A: 633-635, 2006. 2. Miller, W. L. Congenital adrenal hyperplasia. (Letter) New Eng. J. Med. 314: 1321-1322, 1986. 3. Shephard, E. A., Phillips, I. R., Santisteban, I., West, L. F., Palmer, C. N., Ashworth, A., Povey, S. Isolation of a human cytochrome P-450 reductase cDNA clone and localization of the corresponding gene to chromosome 7q11.2. Ann. Hum. Genet. 53: 291-301, 1989.

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Combination SKU	Supplier No.	Size	Conjugation	Your price	Quantity
BHA21000634-1	PB9736	100 ug	-	$370		Add to Cart
BHA21000634-2	PB9736-10ug	10 ug	Sample	$99		Add to Cart
BHA21000634-3	PB9736-Biotin	100 ug	Biotin	$570		Add to Cart
BHA21000634-4	PB9736-Cy3	100 ug	Cy3	$570		Add to Cart
BHA21000634-5	PB9736-Dylight488	100 ug	Dylight488	$570		Add to Cart
BHA21000634-6	PB9736-Dylight550	100 ug	Dylight550	$570		Add to Cart
BHA21000634-7	PB9736-Dylight594	100 ug	Dylight594	$570		Add to Cart
BHA21000634-8	PB9736-FITC	100 ug	FITC	$570		Add to Cart
BHA21000634-9	PB9736-HRP	100 ug	HRP	$570		Add to Cart
BHA21000634-10	PB9736-APC	100 ug	APC	$670		Add to Cart
BHA21000634-11	PB9736-PE	100 ug	PE	$670		Add to Cart
BHA21000634-12	PB9736-iFluor647	100 ug	iFluor647	$670		Add to Cart
BHA21000634-13	PB9736-carrier-free	100 ug	carrier-free	$370		Add to Cart

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