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Home / Primary Antibodies / Polyclonal Antibodies

Anti-Cytochrome P450 3A4/CYP3A4 Antibody Picoband®

SKU : BHA21000960

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Mfr.No.	PB10055, PB10055-10ug, PB10055-Biotin, PB10055-Cy3, PB10055-Dylight488, PB10055-Dylight550, PB10055-Dylight594, PB10055-FITC, PB10055-HRP, PB10055-APC, PB10055-PE, PB10055-iFluor647, PB10055-carrier-free
Alternative Names	Cytochrome P450 3A4
Background	Cytochrome P450 3A4 (abbreviated CYP3A4), is an important enzyme in the body, mainly found in the liver and in the intestine. This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases that catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and its expression is induced by glucocorticoids and some pharmacological agents. This enzyme is involved in the metabolism of approximately half the drugs in use today, including acetaminophen, codeine, cyclosporin A, diazepam and erythromycin. The enzyme also metabolizes some steroids and carcinogens. This gene is part of a cluster of cytochrome P450 genes on chromosome 7q21.1. Previously another CYP3A gene, CYP3A3, was thought to exist; however, it is now thought that this sequence represents a transcript variant of CYP3A4. Alteatively spliced transcript variants encoding different isoforms have been identified.
Clonality	Polyclonal
Cross Reactivity	No cross-reactivity with other proteins
Description	Boster Bio Anti-Cytochrome P450 3A4/CYP3A4 Antibody Picoband® catalog # PB10055. Tested in IHC, WB applications. This antibody reacts with Human. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Weste blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
Function	Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It performs a variety of oxidation reactions (e.g. caffeine 8-oxidation, omeprazole sulphoxidation
Host	Rabbit
Immunogen Region	A synthetic peptide corresponding to a sequence in the middle region of human CYP3A4.
Isotype	Rabbit IgG
Molecular Weight	57 kDa
Reactivity	Human
Reconstitution	Add 0.2ml of distilled water will yield a concentration of 500ug/ml.
Specificity	No cross reactivity with other proteins.
Synonyms	Cytochrome P450 3A4;1.14.13.-;1,8-cineole 2-exo-monooxygenase;1.14.13.157;Albendazole monooxygenase;1.14.13.32;Albendazole sulfoxidase;CYPIIIA3;CYPIIIA4;Cholesterol 25-hydroxylase ;1.14.14.1 ;Cytochrome P450 3A3;Cytochrome P450 HLp;Cytochrome P450 NF-25;Cytochrome P450-PCN1;Nifedipine oxidase;Quinine 3-monooxygenase;1.14.13.67;Taurochenodeoxycholate 6-alpha-hydroxylase;1.14.13.97;CYP3A4;CYP3A3;
Tissue Specificity	Expressed in prostate and liver. According to some authors, it is not expressed in brain (PubMed:19094056). According to others, weak levels of expression are measured in some brain locations (PubMed:19359404 and PubMed:18545703). Also expressed in epithelium of the small intestine and large intestine, bile duct, nasal mucosa, kidney, adrenal cortex, epithelium of the gastric mucosa with intestinal metaplasia, gallbladder, intercalated ducts of the pancreas, chief cells of the parathyroid and the corpus luteum of the ovary (at protein level). .
Note	Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg NaN3.

Uniprot	P08684
Gene Id	1576
Gene Name	CYP3A4
Subcellular Location	Endoplasmic reticulum membrane; Single-pass membrane protein. Microsome membrane ; Single-pass membrane protein.

Conjugates	Biotin, Cy3, Dylight488, Dylight550, Dylight594, FITC, HRP, APC, PE, iFluor647, carrier-free

Concentration	Adding 0.2 ml of distilled water will yield a concentration of 500 ug/ml.
Form	Lyophilized
Purification	Immunogen affinity purified.
Storage	Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Applications	IHC, WB
Description	Immunohistochemistry (Paraffin-embedded Section), 0.5-1ug/ml, Human, By Heat Weste blot, 0.1-0.5ug/ml, Human

Reference	1. Hashimoto H, Toide K, Kitamura R, Fujita M, Tagawa S, Itoh S, Kamataki T (December 1993). "Gene structure of CYP3A4, an adult-specific form of cytochrome P450 in human livers, and its transcriptional control". Eur. J. Biochem. 218 (2): 58595. 2. Inoue K, Inazawa J, Nakagawa H, Shimada T, Yamazaki H, Guengerich FP, Abe T (June 1992). "Assignment of the human cytochrome P-450 nifedipine oxidase gene (CYP3A4) to chromosome 7 at band q22.1 by fluorescence in situ hybridization". Jpn. J. Hum. Genet. 37 (2): 1338.

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Combination SKU	Supplier No.	Size	Conjugation	Your price	Quantity
BHA21000960-1	PB10055	100 ug	-	$370		Add to Cart
BHA21000960-2	PB10055-10ug	10 ug	Sample	$99		Add to Cart
BHA21000960-3	PB10055-Biotin	100 ug	Biotin	$570		Add to Cart
BHA21000960-4	PB10055-Cy3	100 ug	Cy3	$570		Add to Cart
BHA21000960-5	PB10055-Dylight488	100 ug	Dylight488	$570		Add to Cart
BHA21000960-6	PB10055-Dylight550	100 ug	Dylight550	$570		Add to Cart
BHA21000960-7	PB10055-Dylight594	100 ug	Dylight594	$570		Add to Cart
BHA21000960-8	PB10055-FITC	100 ug	FITC	$570		Add to Cart
BHA21000960-9	PB10055-HRP	100 ug	HRP	$570		Add to Cart
BHA21000960-10	PB10055-APC	100 ug	APC	$670		Add to Cart
BHA21000960-11	PB10055-PE	100 ug	PE	$670		Add to Cart
BHA21000960-12	PB10055-iFluor647	100 ug	iFluor647	$670		Add to Cart
BHA21000960-13	PB10055-carrier-free	100 ug	carrier-free	$370		Add to Cart

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