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Home / Primary Antibodies / Polyclonal Antibodies

Anti-Cytochrome p450 2C19/CYP2C19 Antibody Picoband®

SKU : BHA21002217

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Mfr.No.	A02102-2, A02102-2-10ug, A02102-2-Biotin, A02102-2-Cy3, A02102-2-Dylight488, A02102-2-Dylight550, A02102-2-Dylight594, A02102-2-FITC, A02102-2-HRP, A02102-2-APC, A02102-2-PE, A02102-2-iFluor647, A02102-2-carrier-free
Alternative Names	cytochrome P450 family 2 subfamily C member 19
Background	Cytochrome P450 2C19 (abbreviated CYP2C19) encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and is known to metabolize many xenobiotics, including the anticonvulsive drug mephenytoin, omeprazole, diazepam and some barbiturates. Polymorphism within this gene is associated with variable ability to metabolize mephenytoin, known as the poor metabolizer and extensive metabolizer phenotypes. The gene is located within a cluster of cytochrome P450 genes on chromosome 10q24.
Clonality	Polyclonal
Cross Reactivity	No cross-reactivity with other proteins.
Description	Boster Bio Anti-Cytochrome p450 2C19/CYP2C19 Antibody catalog # A02102-2. Tested in IHC, WB applications. This antibody reacts with Human, Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Weste blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
Function	Responsible for the metabolism of a number of therapeutic agents such as the anticonvulsant drug S-mephenytoin, omeprazole, proguanil, certain barbiturates, diazepam, propranolol, citalopram and imipramine.
Host	Rabbit
Immunogen Region	A synthetic peptide corresponding to a sequence in the middle region of human Cytochrome p450 2C19/CYP2C19.
Isotype	Rabbit IgG
Molecular Weight	56 kDa
Reactivity	Human, Mouse, Rat
Reconstitution	Add 0.2ml of distilled water will yield a concentration of 500ug/ml.
Specificity	No cross reactivity with other proteins.
Synonyms	Cytochrome P450 2C19; (R)-limonene 6-monooxygenase; (S)-limonene 6-monooxygenase; S)-limonene 7-monooxygenase; CYPIIC17; CYPIIC19; Cytochrome P450-11A; Cytochrome P450-254C; Mephenytoin 4-hydroxylase; CYP2C19
Tissue Specificity	P450 can be induced to high levels in liver and other tissues by various foreign compounds, including drugs, pesticides, and carcinogens.
Note	Each vial contains 4mg Trehalose, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg NaN3.

Uniprot	P33261
Gene Id	1557
Gene Name	CYP2C19
Subcellular Location	Endoplasmic reticulum membrane. Peripheral membrane protein. Microsome membrane. Peripheral membrane protein.

Conjugates	Biotin, Cy3, Dylight488, Dylight550, Dylight594, FITC, HRP, APC, PE, iFluor647, carrier-free

Concentration	Adding 0.2 ml of distilled water will yield a concentration of 500 ug/ml.
Form	Lyophilized
Purification	Immunogen affinity purified.
Storage	Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Applications	IHC, WB
Description	Weste blot, 0.1-0.5ug/ml<br> Immunohistochemistry (Paraffin-embedded Section), 0.5-1ug/ml<br>

Reference	1. "Entrez Gene: CYP2C19 cytochrome P450, family 2, subfamily C, polypeptide 19".<br /><br />2. Fleming I (October 2014). "The pharmacology of the cytochrome P450 epoxygenase/soluble epoxide hydrolase axis in the vasculature and cardiovascular disease". Pharmacological Reviews. 66 (4): 110640.

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Combination SKU	Supplier No.	Conjugation	Size	Your price	Quantity
BHA21002217-1	A02102-2	-	100 ug	$370		Add to Cart
BHA21002217-2	A02102-2-10ug	Sample	10 ug	$99		Add to Cart
BHA21002217-3	A02102-2-Biotin	Biotin	100 ug	$570		Add to Cart
BHA21002217-4	A02102-2-Cy3	Cy3	100 ug	$570		Add to Cart
BHA21002217-5	A02102-2-Dylight488	Dylight488	100 ug	$570		Add to Cart
BHA21002217-6	A02102-2-Dylight550	Dylight550	100 ug	$570		Add to Cart
BHA21002217-7	A02102-2-Dylight594	Dylight594	100 ug	$570		Add to Cart
BHA21002217-8	A02102-2-FITC	FITC	100 ug	$570		Add to Cart
BHA21002217-9	A02102-2-HRP	HRP	100 ug	$570		Add to Cart
BHA21002217-10	A02102-2-APC	APC	100 ug	$670		Add to Cart
BHA21002217-11	A02102-2-PE	PE	100 ug	$670		Add to Cart
BHA21002217-12	A02102-2-iFluor647	iFluor647	100 ug	$670		Add to Cart
BHA21002217-13	A02102-2-carrier-free	carrier-free	100 ug	$370		Add to Cart

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