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Home / Primary Antibodies / Polyclonal Antibodies

Anti-CYP7A1 Antibody Picoband®

SKU : BHA21002821

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Mfr.No.	A01601, A01601-10ug, A01601-Biotin, A01601-Cy3, A01601-Dylight488, A01601-Dylight550, A01601-Dylight594, A01601-FITC, A01601-HRP, A01601-APC, A01601-PE, A01601-iFluor647, A01601-carrier-free
Alternative Names	Multidrug resistance-associated protein 4
Background	CYP7A1 (Cytochrome P450 Subfamily VIIA Polypeptide 1), also called CYP7 or CHOLESTEROL 7-ALPHA-HYDROXYLASE, is an enzyme that in humans is encoded by the CYP7A1 gene. Using both mouse-human somatic cell hybrids and in situ chromosomal hybridization, Cohen et al. (1992) mapped the CYP7 gene to 8q11-q12. By transfection of reporter constructs, mutation analysis, and DNase footprinting, Molowa et al. (1992) identified areas of the CYP7A1 promoter region that showed hepatocyte-specific activation. They found HNF3 to be an activator of CYP7A1 activity. Agellon et al. (2002) found that wildtype mice and mice transgenic for human CYP7A1 respond differently to cholesterol feeding. Cholesterol feeding stimulated Cyp7a1 mRNA abundance and enzymatic activity in wildtype mice, but repressed human CYP7A1 mRNA and activity in transgenic mice.
Clonality	Polyclonal
Cross Reactivity	No cross-reactivity with other proteins.
Description	Boster Bio Anti-CYP7A1 Antibody Picoband® catalog # A01601. Tested in ELISA, Flow Cytometry, IF, IHC, ICC, WB applications. This antibody reacts with Human. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Weste blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
Function	May be an organic anion pump relevant to cellular detoxification.
Host	Rabbit
Immunogen Region	E.coli-derived human CYP7A1 recombinant protein (Position: I10-L504).
Isotype	Rabbit IgG
Molecular Weight	58 kDa
Reactivity	Human
Reconstitution	Add 0.2ml of distilled water will yield a concentration of 500ug/ml.
Synonyms	Multidrug resistance-associated protein 4;ATP-binding cassette sub-family C member 4;MRP/cMOAT-related ABC transporter;Multi-specific organic anion transporter B;MOAT-B;ABCC4;MRP4;
Tissue Specificity	Widely expressed, with particularly high levels in prostate, but is barely detectable in liver.
Note	Each vial contains 4 mg Trehalose, 0.9 mg NaCl and 0.2 mg Na2HPO4.

Uniprot	P22680
Gene Id	1581
Gene Name	CYP7A1
Subcellular Location	Membrane; Multi-pass membrane protein.

Conjugates	Biotin, Cy3, Dylight488, Dylight550, Dylight594, FITC, HRP, APC, PE, iFluor647, carrier-free

Concentration	Adding 0.2 ml of distilled water will yield a concentration of 500 ug/ml.
Form	Lyophilized
Purification	Immunogen affinity purified.
Storage	Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Applications	ELISA, Flow Cytometry, IF, IHC, ICC, WB
Description	Weste blot, 0.25-0.5ug/ml, Human<br> Immunohistochemistry(Paraffin-embedded Section, 2-5 ug/ml, Human<br> Immunocytochemistry/Immunofluorescence, 5 ug/ml, Human<br> Flow Cytometry (Fixed), 1-3ug/1x10<sup>6</sup> cells, Human<br> ELISA, 0.1-0.5ug/ml, -<br>

Reference	1. Agellon, L. B., Drover, V. A. B., Cheema, S. K., Gbaguidi, G. F., Walsh, A. Dietary cholesterol fails to stimulate the human cholesterol 7-alpha-hydroxylase gene (CYP7A1) in transgenic mice. J. Biol. Chem. 277: 20131-20134, 2002.<br /><br />2. Cohen, J. C., Cali, J. J., Jelinek, D. F., Mehrabian, M., Sparkes, R. S., Lusis, A. J., Russell, D. W., Hobbs, H. H. Cloning of the human cholesterol 7-alpha-hydroxylase gene (CYP7) and localization to chromosome 8q11-q12. Genomics 14: 153-161, 1992.<br /><br />3. Molowa, D. T., Chen, W. S., Cimis, G. M., Tan, C. P. Transcriptional regulation of the human cholesterol 7 alpha-hydroxylase gene. Biochemistry 31: 2539-2544, 1992.<br /><br />

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Combination SKU	Supplier No.	Conjugation	Size	Your price	Quantity
BHA21002821-1	A01601	-	100 ug	$370		Add to Cart
BHA21002821-2	A01601-10ug	Sample	10 ug	$99		Add to Cart
BHA21002821-3	A01601-Biotin	Biotin	100 ug	$570		Add to Cart
BHA21002821-4	A01601-Cy3	Cy3	100 ug	$570		Add to Cart
BHA21002821-5	A01601-Dylight488	Dylight488	100 ug	$570		Add to Cart
BHA21002821-6	A01601-Dylight550	Dylight550	100 ug	$570		Add to Cart
BHA21002821-7	A01601-Dylight594	Dylight594	100 ug	$570		Add to Cart
BHA21002821-8	A01601-FITC	FITC	100 ug	$570		Add to Cart
BHA21002821-9	A01601-HRP	HRP	100 ug	$570		Add to Cart
BHA21002821-10	A01601-APC	APC	100 ug	$670		Add to Cart
BHA21002821-11	A01601-PE	PE	100 ug	$670		Add to Cart
BHA21002821-12	A01601-iFluor647	iFluor647	100 ug	$670		Add to Cart
BHA21002821-13	A01601-carrier-free	carrier-free	100 ug	$370		Add to Cart

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