Specificity: This Polyclonal antibody is directed against human COX 2 protein. The product was purified from serum by protein A chromatography. Expect reactivity with human COX 2. Cross-reactivity with COX 2 from other sources has not been determined.Relevance: Cyclooxygenase 2(COX2) is an inducible enzyme. It is involved in the response of cells to growth factors, tumor promoters, and cytokines that induce its expression. Given its role in synthesizing prostaglandins, COX2 is therefore of interest in studying immune response regulation. COX2 is induced by a wide variety of stimuli and was initially identified as immediate early growth response gene. In addition, COX2 expression markedly increased in 85-90% of human colorectal adenocarcinoma whereas COX1 levels remain unchanged.
Format
Liquid
Purity
Affinity purified
Storage
This product is stable for several weeks at 4°C as an undiluted liquid. Dilute only prior to immediate use. For extended storage, aliquot contents and freeze at -20°C or below. Avoid cycles of freezing and thawing. Expiration date is one (1) year from date of receipt.
Storage Condition
-20C
Applications
WB
Description
Recommended dilutionsWB: 1/1000~4000Predicted molecular weight: 69 kDa.Not yet tested in other applications.Optimal dilutions/concentrations should be determined by the end user., WB