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Home / Primary Antibodies / Polyclonal Antibodies

Anti-Cyclin-dependent kinase 4 Cdk4 Antibody Picoband®

SKU : BHA21006786

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Mfr.No.	PA1428-1, PA1428-1-10ug, PA1428-1-Biotin, PA1428-1-Cy3, PA1428-1-Dylight488, PA1428-1-Dylight550, PA1428-1-Dylight594, PA1428-1-FITC, PA1428-1-HRP, PA1428-1-APC, PA1428-1-PE, PA1428-1-iFluor647, PA1428-1-carrier-free
Alternative Names	Cyclin-dependent kinase 4
Background	Cyclin-dependent kinase-4 (CDK4) is a protein-serine kinase involved in the cell cycle. Human cell division is regulated primarily at the G1-to-S or the G2-to-M boundaries within the cell cycle. The complexes formed by CDK4 and the D-type cyclins are involved in the control of cell proliferation during the G1 phase. CDK4 is inhibited by p16, also known as cyclin-dependent kinase inhibitor-2. CDK4 is mapped to 12q14. CDK4 expression and activity are required for cytokine responsiveness in T cells.
Clonality	Polyclonal
Cross Reactivity	No cross-reactivity with other proteins
Description	Boster Bio Anti-Cyclin-dependent kinase 4 Cdk4 Antibody catalog # PA1428-1. Tested in Flow Cytometry, IF, ICC, WB applications. This antibody reacts with Human, Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Weste blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
Function	Ser/Thr-kinase component of cyclin D-CDK4 (DC) complexes that phosphorylate and inhibit members of the retinoblastoma (RB) protein family including RB1 and regulate the cell-cycle during G (1)/S transition. Phosphorylation of RB1 allows dissociation of th
Host	Rabbit
Immunogen Region	A synthetic peptide corresponding to a sequence at the C-terminus of mouse Cdk4, different from the related rat sequence by one amino acid, and from the related human sequence by four amino acids.
Isotype	Rabbit IgG
Molecular Weight	34 kDa
Reactivity	Human, Mouse, Rat
Reconstitution	Add 0.2ml of distilled water will yield a concentration of 500ug/ml.
Synonyms	Cyclin-dependent kinase 4;2.7.11.22;CRK3;Cell division protein kinase 4;PSK-J3;Cdk4;Crk3;
Tissue Specificity	Expressed (at protein level) in a wide range of tissues with highest levels in brain, spinal cord, testis, pancreas, heart, spleen and mammary glands. Moderate levels found in thymus, ovary and small intestine. Not detected in salivary gland, muscle or liver. Also expressed in cell lines of myeloid, fibroblast and epithelial origin. Not detected in most lymphoid cell lines. .
Note	Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3.

Uniprot	P30285
Gene Name	CDK4
Sequence	Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.
Subcellular Location	Cytoplasm . Nucleus . Membrane . Cytoplasmic when non- complexed. Forms a cyclin D-CDK4 complex in the cytoplasm as cells progress through G (1) phase. The complex accumulates on the nuclear membrane and enters the nucleus on transition from G (1) to S phase. Also present in nucleoli and heterochromatin lumps. Colocalizes with RB1 after release into the nucleus (By similarity). .

Conjugates	Biotin, Cy3, Dylight488, Dylight550, Dylight594, FITC, HRP, APC, PE, iFluor647, carrier-free

Concentration	Adding 0.2 ml of distilled water will yield a concentration of 500 ug/ml.
Form	Lyophilized
Purification	Immunogen affinity purified.
Storage	Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Applications	Flow Cytometry, IF, ICC, WB
Description	Weste blot, 0.1-0.5ug/ml, Human, Mouse, Rat<br> Immunocytochemistry/Immunofluorescence, 5 ug/ml, Human<br> Flow Cytometry (Fixed), 1-3 ug/1x10<sup>6</sup> cells, Human<br>

Reference	1. Demetrick, D. J.; Zhang, H.; Beach, D. H. : Chromosomal mapping of human CDK2, CDK4, and CDK5 cell cycle kinase genes. Cytogenet. Cell Genet. 66: 72-74, 1994.<br /><br />2. Modiano, J. F.; Mayor, J.; Ball, C.; Fuentes, M. K.; Linthicum, D. S. : CDK4 expression and activity are required for cytokine responsiveness in T cells. J. Immun. 165: 6693-6702, 2000.e for human proliferating nuclear antigen/cyclin by in situ hybridization. Hum. Genet. 86: 84-86, 1990.<br /><br />

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Combination SKU	Supplier No.	Conjugation	Size	Your price	Quantity
BHA21006786-1	PA1428-1	-	100 ug	$370		Add to Cart
BHA21006786-2	PA1428-1-10ug	Sample	10 ug	$99		Add to Cart
BHA21006786-3	PA1428-1-Biotin	Biotin	100 ug	$570		Add to Cart
BHA21006786-4	PA1428-1-Cy3	Cy3	100 ug	$570		Add to Cart
BHA21006786-5	PA1428-1-Dylight488	Dylight488	100 ug	$570		Add to Cart
BHA21006786-6	PA1428-1-Dylight550	Dylight550	100 ug	$570		Add to Cart
BHA21006786-7	PA1428-1-Dylight594	Dylight594	100 ug	$570		Add to Cart
BHA21006786-8	PA1428-1-FITC	FITC	100 ug	$570		Add to Cart
BHA21006786-9	PA1428-1-HRP	HRP	100 ug	$570		Add to Cart
BHA21006786-10	PA1428-1-APC	APC	100 ug	$670		Add to Cart
BHA21006786-11	PA1428-1-PE	PE	100 ug	$670		Add to Cart
BHA21006786-12	PA1428-1-iFluor647	iFluor647	100 ug	$670		Add to Cart
BHA21006786-13	PA1428-1-carrier-free	carrier-free	100 ug	$370		Add to Cart

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