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Home / Primary Antibodies / Polyclonal Antibodies

Anti-COMT Antibody Picoband®

SKU : BHA21001901

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Mfr.No.	A00464, A00464-10ug, A00464-Biotin, A00464-Cy3, A00464-Dylight488, A00464-Dylight550, A00464-Dylight594, A00464-FITC, A00464-HRP, A00464-APC, A00464-PE, A00464-iFluor647, A00464-carrier-free
Alternative Names	catechol-O-methyltransferase
Background	Catechol O-methyltransferase, also called COMT, is one of the major mammalian enzymes involved in the metabolic degradation of catecholamines. This gene is mapped to 22q11.21. Catechol-O-methyltransferase catalyzes the transfer of a methyl group from S-adenosylmethionine to catecholamines, including the neurotransmitters dopamine, epinephrine, and norepinephrine. This O-methylation results in one of the major degradative pathways of the catecholamine transmitters. In addition to its role in the metabolism of endogenous substances, COMT is important in the metabolism of catechol drugs used in the treatment of hypertension, asthma, and Parkinson disease. COMT is found in two forms in tissues, a soluble form (S-COMT) and a membrane-bound form (MB-COMT). The differences between S-COMT and MB-COMT reside within the N-termini.
Clonality	Polyclonal
Cross Reactivity	No cross-reactivity with other proteins.
Description	Boster Bio Anti-COMT Antibody Picoband® catalog # A00464. Tested in ELISA, WB applications. This antibody reacts with Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Weste blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
Function	Catalyzes the O-methylation, and thereby the inactivation, of catecholamine neurotransmitters and catechol hormones. Also shortens the biological half-lives of certain neuroactive drugs, like L-DOPA, alpha-methyl DOPA and isoproterenol.
Host	Rabbit
Immunogen Region	E. coli-derived mouse COMT recombinant protein (Position: R20-S265).
Isotype	Rabbit IgG
Molecular Weight	25 kDa, 29 kDa
Reactivity	Mouse, Rat
Reconstitution	Add 0.2ml of distilled water will yield a concentration of 500ug/ml.
Specificity	No cross reactivity with other proteins.
Synonyms	Catechol O-methyltransferase; Comt; Comt1
Note	Each vial contains 4mg Trehalose, 0.9mg NaCl, 0.2mg Na<sub>2</sub>HPO<sub>4</sub>, 0.05mg NaN<sub>3</sub>.

Uniprot	O88587
Gene Id	12846
Gene Name	Comt
Subcellular Location	Isoform Soluble: Cytoplasm.

Conjugates	Biotin, Cy3, Dylight488, Dylight550, Dylight594, FITC, HRP, APC, PE, iFluor647, carrier-free

Concentration	Adding 0.2 ml of distilled water will yield a concentration of 500 ug/ml.
Form	Lyophilized
Purification	Immunogen affinity purified.
Storage	Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Applications	WB, ELISA
Description	Weste blot, 0.1-0.5ug/ml<br> ELISA, 0.1-0.5ug/ml<br>

Reference	1. Baker, K., Baldeweg, T., Sivagnanasundaram, S., Scambler, P., Skuse, D. COMT val108/158met modifies mismatch negativity and cognitive function in 22q11 deletion syndrome. Biol. Psychiat. 58: 23-31, 2005.<br /><br />2. Lee, S.-G., Joo, Y., Kim, B., Chung, S., Kim, H.-L., Lee, I., Choi, B., Kim, C., Song, K.Association of Ala72Ser polymorphism with COMT enzyme activity and the risk of schizophrenia in Koreans. Hum. Genet. 116: 319-328, 2005.

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Combination SKU	Supplier No.	Size	Conjugation	Your price	Quantity
BHA21001901-1	A00464	100 ug	-	$370		Add to Cart
BHA21001901-2	A00464-10ug	10 ug	Sample	$99		Add to Cart
BHA21001901-3	A00464-Biotin	100 ug	Biotin	$570		Add to Cart
BHA21001901-4	A00464-Cy3	100 ug	Cy3	$570		Add to Cart
BHA21001901-5	A00464-Dylight488	100 ug	Dylight488	$570		Add to Cart
BHA21001901-6	A00464-Dylight550	100 ug	Dylight550	$570		Add to Cart
BHA21001901-7	A00464-Dylight594	100 ug	Dylight594	$570		Add to Cart
BHA21001901-8	A00464-FITC	100 ug	FITC	$570		Add to Cart
BHA21001901-9	A00464-HRP	100 ug	HRP	$570		Add to Cart
BHA21001901-10	A00464-APC	100 ug	APC	$670		Add to Cart
BHA21001901-11	A00464-PE	100 ug	PE	$670		Add to Cart
BHA21001901-12	A00464-iFluor647	100 ug	iFluor647	$670		Add to Cart
BHA21001901-13	A00464-carrier-free	100 ug	carrier-free	$370		Add to Cart

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