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Home / Primary Antibodies / Polyclonal Antibodies

Anti-CNGA4 Antibody

SKU : BHA21300995

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Mfr.No.	APC-074, APC-074-CF_0.2 ml, APC-074_0.2 ml, APC-074_50 mcl
Lead Time	1-2 Business Days
Immunogen Species	Rat
Background	Cyclic Nucleotide-Gated (CNG) channels belong to the superfamily of voltage-gated ion channels. Although permeable to various ions such as the monovalent Na+ and K+ ions, and the divalent Ca2+ ion, they are gated by the intracellular binding of the cyclic nucleotides cAMP and cGMP and not by voltage per se (CNGs bind preferably to cGMP)1.Six channels form this subfamily: The A subunit (CNGA1-4) and the B subunit (CNGB1 and CNGB3). Functional entities are formed by the assembly of four subunits. Each subunit consists of six membrane spanning domains, where the fourth transmembrane domain is highly positively charged, a pore domain between transmembrane domains five and six, and intracellular N- and C-termini. The cyclic nucleotide binding domain is located in the C-terminal region and is responsible for the channel gating upon cyclic nucleotide binding1.These channels are highly expressed in retinal photoreceptors and olfactory neurons where their role has been extensively studied2. CNG channels have also been detected in brain, testis and kidney although their role in these tissues has yet to be unraveled2. When heterologously expressed all subunits with exception of CNGA4, CNGB1 and CNGB3 can form functional homomeric channels. In olfactory sensory neurons, CNG channels which are formed by two CNGA2, one CNGA4 subunits and an isoform of CNGB1, are activated by the binding of cAMP, whose levels increase in response to the binding of odorant molecules to their respective receptors1,3.CNGA4 knockout mice are fertile and morphologically similar to their wild type littermates4,5. In these mice, the olfactory bulb and epithelium are developed but these mice display defects in odor adaptation, and at the molecular level, they are less sensitive to cAMP activation6.
Clonality	Polyclonal
Description	Anti-CNGA4 Antibody (#APC-074) is a highly specific antibody directed against an epitope of the rat protein. The antibody can be used in western blot and immunohistochemistry applications. It has been designed to recognize CNGA4 from human, rat, and mouse samples.
Formulation	PBS pH7.4
Host	Rabbit
Immunogen Region	Intracellular, N-terminus
Isotype	Rabbit IgG
Reactivity	Rat, Mouse
Reconstitution	0.2 ml double distilled water (DDW).
Shipping	Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C
Synonyms	Cyclic nucleotide-gated cation channel alpha-4, CNG4, Cyclic nucleotide-gated olfactory channel subunit OCNC2, OCNCb
UNSPSC Code	41116161
Note	Homology: Mouse - identical; human - 15/18 amino acid residues identical Peptide confirmation: Confirmed by amino acid analysis and mass spectrometry Negative Control: BLP-PC074 Specifictiy: CNGA4 Is Toxin: No Standard quality control of each lot: Western blot analysis Antigen preadsorption control: 1 ug peptide per 1 ug antibody

Accession Number	Q64359
Gene Id	85258
Target	Cyclic nucleotide-gated cation channel alpha-4, CNG4, Cyclic nucleotide-gated olfactory channel subunit OCNC2, OCNCb
Sequence	(C) SQDGKVKTTESTPPAPTK, corresponding to amino acid residues 2-19 of rat CNGA4

Conjugates	Unconjugated

Concentration	1 mg/ml
Form	Lyophilized powder. Reconstituted antibody contains phosphate buffered saline (PBS), pH 7.4.
Preservative	No Preservative
Purity	Affinity purified on immobilized antigen.
Storage	Storage After Reconstitution: The reconstituted solution can be stored at 4°C for up to 1 week. For longer periods, small aliquots should be stored at -20°C. Avoid multiple freezing and thawing. Centrifuge all antibody preparations before use (10000 x g 5 min). Storage Before Reconstitution: The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20°C

Applications	IF, IHC, WB
Dilution	Contact Alomone for information

Product Manual	SDS

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Combination SKU	Supplier No.	Size	Your price	Quantity
BHA21300995-1	APC-074-CF_0.2 ml	0.2 ml(Carrier Free)	$994		Add to Cart
BHA21300995-2	APC-074_0.2 ml	0.2 ml	$795		Add to Cart
BHA21300995-3	APC-074_50 mcl	50 mcl	$697		Add to Cart

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