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Home / Primary Antibodies / Polyclonal Antibodies

Anti-ClC-5/CLCN5 Antibody Picoband®

SKU : BHA21003330

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Mfr.No.	A02286-2, A02286-2-10ug, A02286-2-Biotin, A02286-2-Cy3, A02286-2-Dylight488, A02286-2-Dylight550, A02286-2-Dylight594, A02286-2-FITC, A02286-2-HRP, A02286-2-APC, A02286-2-PE, A02286-2-iFluor647, A02286-2-carrier-free
Alternative Names	mannose receptor C-type 1
Background	The CLCN5 gene encodes the chloride channel Cl-/H+ exchanger ClC-5. This gene encodes a member of the ClC family of chloride ion channels and ion transporters. The encoded protein is primarily localized to endosomal membranes and may function to facilitate albumin uptake by the renal proximal tubule. Mutations in this gene have been found in Dent disease and renal tubular disorders complicated by nephrolithiasis. Alteatively spliced transcript variants have been found for this gene.
Clonality	Polyclonal
Cross Reactivity	No cross-reactivity with other proteins.
Description	Boster Bio Anti-ClC-5/CLCN5 Antibody Picoband® catalog # A02286-2. Tested in ELISA, WB applications. This antibody reacts with Human, Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Weste blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
Function	Mediates the endocytosis of glycoproteins by macrophages. Binds both sulfated and non-sulfated polysaccharide chains. (Microbial infection) Acts as phagocytic receptor for bacteria, fungi and other pathogens. (Microbial infection) Acts as a receptor for D
Host	Rabbit
Immunogen Region	E.coli-derived human CLCN5 recombinant protein (Position: R100-S756).
Isotype	Rabbit IgG
Molecular Weight	100 kDa
Reactivity	Human, Mouse, Rat
Reconstitution	Add 0.2ml of distilled water will yield a concentration of 500ug/ml.
Synonyms	Macrophage mannose receptor 1; MMR; C-type lectin domain family 13 member D; C-type lectin domain family 13 member D-like; Human mannose receptor; hMR; Macrophage mannose receptor 1-like protein 1; CD206; MRC1; CLEC13D; CLEC13DL; MRC1L1
Tissue Specificity	Ubiquitous.
Note	Each vial contains 4mg Trehalose, 0.9mg NaCl, 0.2mg Na2HPO4.

Uniprot	P51795
Gene Id	1184
Gene Name	CLCN5
Subcellular Location	Cell membrane. Single-pass type I membrane protein. Endosome membrane. Single-pass type I membrane protein.

Conjugates	Biotin, Cy3, Dylight488, Dylight550, Dylight594, FITC, HRP, APC, PE, iFluor647, carrier-free

Concentration	Adding 0.2 ml of distilled water will yield a concentration of 500 ug/ml.
Form	Lyophilized
Purification	Immunogen affinity purified.
Storage	Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Applications	WB, ELISA
Description	Weste blot, 0.25-0.5ug/ml, Mouse, Rat<br> ELISA, 0.1-0.5ug/ml, -<br>

Reference	1. Akuta, N., Lloyd, S. E., Igarashi, T., Shiraga, H., Matsuyama, T., Yokoro, S., Cox, J. P. D., Thakker, R. V. Mutations of CLCN5 in Japanese children with idiopathic low molecular weight proteinuria, hypercalciuria and nephrocalcinosis. Kidney Int. 52: 911-916, 1997. <br /><br />2. Alex, P., Ye, M., Zachos, N. C., Sipes, J., Nguyen, T., Suhodrev, M., Gonzales, L., Arora, Z., Zhang, T., Centola, M., Guggino, S. E., Li, X. Clcn5 knockout mice exhibit novel immunomodulatory effects and are more susceptible to dextran sulfate sodium-induced colitis. J. Immun. 184: 3988-3996, 2010. <br /><br />3. Blair, H. J., Ho, M., Monaco, A. P., Fisher, S., Craig, I. W., Boyd, Y. High-resolution comparative mapping of the proximal region of the mouse X chromosome. Genomics 28: 305-310, 1995.

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Combination SKU	Supplier No.	Conjugation	Size	Your price	Quantity
BHA21003330-1	A02286-2	-	100 ug	$370		Add to Cart
BHA21003330-2	A02286-2-10ug	Sample	10 ug	$99		Add to Cart
BHA21003330-3	A02286-2-Biotin	Biotin	100 ug	$570		Add to Cart
BHA21003330-4	A02286-2-Cy3	Cy3	100 ug	$570		Add to Cart
BHA21003330-5	A02286-2-Dylight488	Dylight488	100 ug	$570		Add to Cart
BHA21003330-6	A02286-2-Dylight550	Dylight550	100 ug	$570		Add to Cart
BHA21003330-7	A02286-2-Dylight594	Dylight594	100 ug	$570		Add to Cart
BHA21003330-8	A02286-2-FITC	FITC	100 ug	$570		Add to Cart
BHA21003330-9	A02286-2-HRP	HRP	100 ug	$570		Add to Cart
BHA21003330-10	A02286-2-APC	APC	100 ug	$670		Add to Cart
BHA21003330-11	A02286-2-PE	PE	100 ug	$670		Add to Cart
BHA21003330-12	A02286-2-iFluor647	iFluor647	100 ug	$670		Add to Cart
BHA21003330-13	A02286-2-carrier-free	carrier-free	100 ug	$370		Add to Cart

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