Recognizes a protein of 165-170kDa, identified as cystic fibrosis transmembrane conductance regulator (CFTR). CFTR is composed of two membrane-spanning domains (MSD), two nucleotide-binding domains (NBD), and an R domain. It is structurally similar to multidrug resistance (Mdr1) protein and both are members of the superfamily of ATP-binding cassette (ABC) transporters, also known as traffic ATPases, which are implicated in the movement of various substrates. The CFTR protein is a small conductance adenosine 3',5'-cyclic monophosphate (cAMP)-activated chloride ion channel found in the apical membranes of epithelia within the pancreas, airway, intestine, bile duct, sweat gland, and male genital ducts. CFTR is a valuable marker of human pancreatic duct cell development and differentiation.
Host
Mouse
Immunogen
Recombinant human CFTR fragment (aa258-385) (exact sequence is proprietary)
Isotype
IgG1
Positive Control
MOLT-4 cells. Pancreas, Kidney or Placenta.
Reactivity
Human
Recombinant
FALSE
Regulatory
RUO
Swissprot
P13569
Uniprot
489786, 621460, 661104
Gene Id
1080
Buffer
200μg/ml of Ab purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA; 0.05% azide. Also available WITHOUT BSA; azide at 1.0mg/ml.
Concentration
1.0mg/ml
Description
There are no warranties, expressed or implied, which extend beyond this description. Company is not liable for any personal injury or economic loss resulting from this product.
Purity
Purified Ab WITHOUT BSA and Azide at 1.0mg/ml
Applications
ELISA, IF
Description
Optimal dilution for a specific application should be determined., ELISA ; IF
Dilution
ELISA
For coating, order Ab without BSA
IF
0.5-1μg/ml
Reviews of Anti-CFTR (Cystic Fibrosis Transmembrane Conductance Regulator) Antibody BHA10200296