This gene encodes a plasma glycoprotein that positively regulates the alternative complement pathway of the innate immune system. This protein binds to many microbial surfaces and apoptotic cells and stabilizes the C3- and C5-convertase enzyme complexes in a feedback loop that ultimately leads to formation of the membrane attack complex and lysis of the target cell. Mutations in this gene result in two forms of properdin deficiency, which results in high susceptibility to meningococcal infections. Multiple alternatively spliced variants, encoding the same protein, have been identified.[provided by RefSeq, Feb 2009]
Host
Mouse
Immunogen
GFP from the jellyfish Aequorea victoria N-Terminal peptide-KLH conjugates (first 20 aa)
Isotype
IgG
Quantity
100 µg
Recombinant
FALSE
Regulatory
RUO
Shipping Condition
Ice Packs
Buffer
PBS, pH 7.4 with 0.02% sodium azide.
Concentration
100µg/100ul
Description
Specificity: Recognizes native and denatured forms of GFP and its variants EGFP, YFP, EYFP, and CFP.Relevance: Has sensitivity of 1-10ng of purified GFP or GFP fusion protein (from a western blot developed with ECL)
Format
Liquid
Purity
Affinity purified
Storage
This product is stable for several weeks at 4°C as an undiluted liquid. Dilute only prior to immediate use. For extended storage, aliquot contents and freeze at -20°C or below. Avoid cycles of freezing and thawing. Expiration date is one (1) year from date of receipt.
Storage Condition
-20C
Applications
WB, IP, ELISA
Description
WB 1:1000. For other applications, the researcher should determine the optimal working dilution., WB ; IP ; ELISA