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Home / Primary Antibodies

Anti-CDKN2A Antibody

SKU : BHA10903007

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Applied Biological Materials (abm) Inc.

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Mfr.No.	Y058399
Categories	Primary Antibodies
Cellular Localization	Nuclear
Clonality	polyclonal
Description	This gene generates several transcript variants which differ in their first exons. At least three alternatively spliced variants encoding distinct proteins have been reported, two of which encode structurally related isoforms known to function as inhibitors of CDK4 kinase. The remaining transcript includes an alternate first exon located 20 Kb upstream of the remainder of the gene; this transcript contains an alternate open reading frame (ARF) that specifies a protein which is structurally unrelated to the products of the other variants. This ARF product functions as a stabilizer of the tumor suppressor protein p53 as it can interact with, and sequester, the E3 ubiquitin-protein ligase MDM2, a protein responsible for the degradation of p53. In spite of the structural and functional differences, the CDK inhibitor isoforms and the ARF product encoded by this gene, through the regulatory roles of CDK4 and p53 in cell cycle G1 progression, share a common functionality in cell cycle G1 control. This gene is frequently mutated or deleted in a wide variety of tumors, and is known to be an important tumor suppressor gene. [provided by RefSeq, Sep 2012]
Host	Rabbit
Immunogen	Rabbit polyclonal CDKN2A antibody was raised against a peptide at the C terminal residues of human CDKN2A protein.
Isotype	IgG
Quantity	100 µl
Reactivity	Human
Recombinant	FALSE
Regulatory	RUO
Shipping Condition	Ice Packs

Buffer	PBS, pH 7.4 with 0.02% Sodium Azide
Concentration	100µg/100ul
Format	Liquid
Purity	Affinity purified
Storage	This product is stable for several weeks at 4°C as an undiluted liquid. Dilute only prior to immediate use. For extended storage, aliquot contents and freeze at -20°C or below. Avoid cycles of freezing and thawing. Expiration date is one (1) year from date of receipt.
Storage Condition	-20C

Applications

IHC, ELISA

Description

For research use only
Peptide ELISA titer: 1:10,000-1:40,000
Immunohistochemistry: 1:50-200
Optimal dilutions/concentrations should be determined by the end use, IHC ; ELISA

Dilution

ELISA	1:10,000-1:40,000
IHC	1:50-200

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SKU	Supplier No.	Size	Your price	Quantity
BHA10903007	Y058399	100 ul	$217.50		Add to Cart

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