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Home / Primary Antibodies

Anti-CDK4 Antibody

SKU : BHA10903189

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Applied Biological Materials (abm) Inc.

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Mfr.No.	Y058190
Categories	Primary Antibodies
Cellular Localization	Nuclear
Clonality	polyclonal
Description	The protein encoded by this gene is a member of the Ser/Thr protein kinase family. This protein is highly similar to the gene products of S. cerevisiae cdc28 and S. pombe cdc2. It is a catalytic subunit of the protein kinase complex that is important for cell cycle G1 phase progression. The activity of this kinase is restricted to the G1-S phase, which is controlled by the regulatory subunits D-type cyclins and CDK inhibitor p16(INK4a). This kinase was shown to be responsible for the phosphorylation of retinoblastoma gene product (Rb). Mutations in this gene as well as in its related proteins including D-type cyclins, p16(INK4a) and Rb were all found to be associated with tumorigenesis of a variety of cancers. Multiple polyadenylation sites of this gene have been reported. [provided by RefSeq, Jul 2008]
Host	Rabbit
Immunogen	Synthetic peptide conjugated to KLH
Isotype	IgG
Quantity	100 µl
Reactivity	Mouse, Human
Recombinant	TRUE
Regulatory	RUO
Shipping Condition	Ice Packs

Buffer	PBS, pH 7.4 with 0.02% Sodium Azide
Concentration	100µg/100ul
Description	Specificity: CDK4 antibody detects endogenous levels of CDK4 protein. Not tested with other proteins Relevance: The protein encoded by this gene is a member of the Ser/Thr protein kinase family. This protein is highly similar to the gene products_recover of S. cerevisiae cdc28 and S. pombe cdc2. It is a catalytic subunit of the protein kinase complex that is important for cell cycle G1 phase progression. The activity of this kinase is restricted to the G1-S phase, which is controlled by the regulatory subunits D-type cyclins and CDK inhibitor p16(INK4a). This kinase was shown to be responsible for the phosphorylation of retinoblastoma gene product (Rb). Mutations in this gene as well as in its related proteins including D-type cyclins, p16(INK4a) and Rb were all found to be associated with tumorigenesis of a variety of cancers. Multiple polyadenylation sites of this gene have been reported.
Format	Liquid
Purity	Affinity purified
Storage	This product is stable for several weeks at 4°C as an undiluted liquid. Dilute only prior to immediate use. For extended storage, aliquot contents and freeze at -20°C or below. Avoid cycles of freezing and thawing. Expiration date is one (1) year from date of receipt.
Storage Condition	-20C

Applications

WB, ELISA

Description

For research use only.
Peptide ELISA titer: 1:8,000-1:20,000
Western blot analysis: 1:200-500
Optimal dilutions/concentrations should be determined by the end use., WB ; ELISA

Dilution

ELISA	1:8,000-1:20,000
WB	1:200-500

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SKU	Supplier No.	Size	Your price	Quantity
BHA10903189	Y058190	100 ul	$217.50		Add to Cart

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