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Home / Primary Antibodies / Polyclonal Antibodies

Anti-CD62P/SELP Antibody Picoband®

SKU : BHA21007001

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Mfr.No.	PA1715, PA1715-10ug, PA1715-Biotin, PA1715-Cy3, PA1715-Dylight488, PA1715-Dylight550, PA1715-Dylight594, PA1715-FITC, PA1715-HRP, PA1715-APC, PA1715-PE, PA1715-iFluor647, PA1715-carrier-free
Alternative Names	P-selectin
Background	P-Selectin, also called CD62, GRMP, GMP140 is a 140-kD adhesion molecule, expressed at the surface of activated cells, that mediates the interaction of activated endothelial cells or platelets with leukocytes. The P-Selectin gene is mapped on 1q24.2. P-selectin plays an essential role in the initial recruitment of leukocytes (white blood cells) to the site of injury during inflammation. P-selectin is also very important in the recruitment and aggregation of platelets at areas of vascular injury. In quiescent platelet, P-selectin is located on the inner wall of alpha-granules. Sorting nexin-17 interacts with the cytosolic domain of P-selectin and suggested that SNX17 may function in the intracellular trafficking of P-selectin. P-selectin expression was found to be significantly and positively correlated with carotid artery stiffness and wall thickness, and the percentage of P-selectin-positive platelets was significantly higher in patients with carotid plaque.
Clonality	Polyclonal
Cross Reactivity	No cross-reactivity with other proteins
Description	Boster Bio Anti-CD62P/SELP Antibody catalog # PA1715. Tested in IHC, WB applications. This antibody reacts with Human. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Weste blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
Function	Ca (2+)-dependent receptor for myeloid cells that binds to carbohydrates on neutrophils and monocytes. Mediates the interaction of activated endothelial cells or platelets with leukocytes. The ligand recognized is sialyl-Lewis X. Mediates rapid rolling of
Host	Rabbit
Immunogen Region	A synthetic peptide corresponding to a sequence at the N-terminus of human CD62P.
Isotype	Rabbit IgG
Molecular Weight	140 kDa
Reactivity	Human
Reconstitution	Add 0.2ml of distilled water will yield a concentration of 500ug/ml.
Specificity	No cross reactivity with other proteins.
Synonyms	P-selectin;CD62 antigen-like family member P;Granule membrane protein 140;GMP-140;Leukocyte-endothelial cell adhesion molecule 3;LECAM3;Platelet activation dependent granule-exteal membrane protein;PADGEM;CD62P;SELP;GMRP, GRMP;
Tissue Specificity	Stored in the alpha-granules of platelets and Weibel-Palade bodies of endothelial cells. Upon cell activation by agonists, P-selectin is transported rapidly to the cell surface.
Note	Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3.

Uniprot	P16109
Gene Name	SELP
Sequence	Belongs to the selectin/LECAM family.
Subcellular Location	Membrane; Single-pass type I membrane protein.

Conjugates	Biotin, Cy3, Dylight488, Dylight550, Dylight594, FITC, HRP, APC, PE, iFluor647, carrier-free

Concentration	Adding 0.2 ml of distilled water will yield a concentration of 500 ug/ml.
Form	Lyophilized
Purification	Immunogen affinity purified.
Storage	Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Applications	IHC, WB
Description	Immunohistochemistry (Paraffin-embedded Section), 0.5-1ug/ml, Human, By Heat<br>Weste blot, 0.1-0.5ug/ml, Human<br>

Reference	1. Burger, P. C., Wagner, D. D. Platelet P-selectin facilitates atherosclerotic lesion development. Blood 101: 2661-2666, 2003.<br /><br />2. Florian, V., Schluter, T., Bohnensack, R. A new member of the sorting nexin family interacts with the C-terminus of P-selectin. Biochem. Biophys. Res. Commun. 281: 1045-1050, 2001. <br /><br />3. Hillis, G. S., Terregino, C., Taggart, P., Killian, A., Zhao, N., Dalsey, W. C., Mangione, A.Elevated soluble P-selectin levels are associated with an increased risk of early adverse effects in patients with presumed myocardial ischemia. Am. Heart J. 143: 235-241, 2002.<br /><br />

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Combination SKU	Supplier No.	Conjugation	Size	Your price	Quantity
BHA21007001-1	PA1715	-	100 ug	$370		Add to Cart
BHA21007001-2	PA1715-10ug	Sample	10 ug	$99		Add to Cart
BHA21007001-3	PA1715-Biotin	Biotin	100 ug	$570		Add to Cart
BHA21007001-4	PA1715-Cy3	Cy3	100 ug	$570		Add to Cart
BHA21007001-5	PA1715-Dylight488	Dylight488	100 ug	$570		Add to Cart
BHA21007001-6	PA1715-Dylight550	Dylight550	100 ug	$570		Add to Cart
BHA21007001-7	PA1715-Dylight594	Dylight594	100 ug	$570		Add to Cart
BHA21007001-8	PA1715-FITC	FITC	100 ug	$570		Add to Cart
BHA21007001-9	PA1715-HRP	HRP	100 ug	$570		Add to Cart
BHA21007001-10	PA1715-APC	APC	100 ug	$670		Add to Cart
BHA21007001-11	PA1715-PE	PE	100 ug	$670		Add to Cart
BHA21007001-12	PA1715-iFluor647	iFluor647	100 ug	$670		Add to Cart
BHA21007001-13	PA1715-carrier-free	carrier-free	100 ug	$370		Add to Cart

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