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Home / Antibodies

Anti-CD3 Antibody

SKU : BHA10921298

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Applied Biological Materials (abm) Inc.

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Mfr.No.	Y059047
Categories	Primary Antibodies
Clonality	monoclonal
Description	CD3 complex is crucial in transducing antigen-recognition signals into the cytopasm of T cells and in regulating the cell surface expression of the TCR complex. T cell activation through the antigen receptor (TCR) involves the cytoplasmic tails of the CD3 subunits CD3 gamma, CD3 delta, CD3 epsilon and CD3 zeta. These CD3 subunits are structurally related members of the immunoglobulins super family encoded by closely linked genes on human chromosome 11. The CD3 components have long cytoplasmic tails that associate with cytoplasmic signal transduction molecules. This association is mediated at least in part by a double tyrosine-based motif present in a single copy in the CD3 subunits. CD3 may play a role in TCR-induced growth arrest, cell survival and proliferation.The CD3 antigen is present on 68-82% of normal peripheral blood lymphocytes, 65-85% of thymocytes and Purkinje cells in the cerebellum. It is never expressed on B or NK cells. Decreased percentages of T lymphocytes may be observed in some autoimmune diseases.
Formulation	Liquid
Host	Mouse(Mu)
Guarantee	abm guarantees that all our Anti-CD3 Antibody will perform as described on this product webpage, if this is not the case we will provide you with a one-time replacement at no extra cost. Documentation and explanation of experiment conducted will be required when submitting a claim for replacement.
Immunogen	Human thymocytes and T lymphocytes
Isotype	IgG2a
Quantity	100 μg
Recommended Dilution	- Flow Cytometry 1:500(Positive control: Peripheral Blood Lymphocytes, JURKAT human leukemia T cell line)- Immunoprecipitation: The antibody immunoprecipitates from a detergent lysate of surface-radioiodinated T cells a strong zone of about 22 kDa and a weak 28-kDa zone, which is typical pattern yielded by a reference antibody Leu-4.- Functional Application: The antibody has strong mitogenic effect on peripheral T lymphocytes; it reacts strongly with gamma delta T lymphocytes.
Shipping Condition	Ice Packs
Species Reactivity	Human
Specificity	The antibody reacts with gamma epsilon and delta epsilon dimers of human CD3 complex, a part of a bigger multisubunit complex of the T cell receptor (CD3/TCR) expressed on peripheral blood T lymphocytes and mature thymocytes. It reacts strongly with gamma delta T lymphocytes.

Gene Name	CD3
Clone No	Monoclonal

Concentration	1µg/ul
Purity	Affinity purified
Storage	This product is stable for several weeks at 4°C as an undiluted liquid. Dilute only prior to immediate use. For extended storage, aliquot contents and freeze at -20°C or below. Avoid cycles of freezing and thawing. Expiration date is one (1) year from date of receipt.
Storage Buffer	PBS, pH 7.4 with 0.05% sodium azide.
Storage Condition	-20C

Description	FACS ; IP

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SKU	Supplier No.	Size	Your price	Quantity
BHA10921298	Y059047	100 ug	$615		Add to Cart

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