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Home / Primary Antibodies / Monoclonal Antibodies

Anti-CD28 Agonist Antibody (Humanized)

SKU : BHA18200036

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BPS Bioscience

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Mfr.No.	100186-1
Background	The T cell-specific receptor CD28 is an important regulator of the immune system. The ligation of CD28 and its ligands CD80/CD86 on the APC provides a critical costimulatory signal alongside T cell receptor (TCR) for T cell activation. The costimulatory signal can also be delivered by the interaction between CD28 and its agonist antibody.
Clonality	Monoclonal
Description	Recombinant monoclonal antibody recognizing human CD28. This antibody binds to CD28 on T cells and promotes T cell response. Not tested in other species. This antibody crosslinked with FcGR2B is useful for activation of CD27 costimulatory pathway in T cells. This antibody has been humanized to reduce immunogenicity and improve the therapeutic half-life. assay conditions: Serial dilutions of anti-CD3 (BPS Bioscience, #71274) and CD28 antibodies were added to the IL-2 reporter-Jurkat cells, then incubated at 37°C incubator for 16 hrs. After the treatment, perform Luciferase assay using One-Step Luciferase assay system (BPS Bioscience, #60690)
Formulation	8 mM Na Phosphate pH 7.4, 110 mM NaCl, 2.2 mM KCl and 20% glycerol
Molecular Weight	Heavy Chain: 51 kDa; Light Chain: 27 kDa
Species	Human
Synonyms	T-Cell-Specific Surface Glycoprotein, TP44
Note	Avoid freeze/thaw cycles.

Uniprot	P10747

Format	Aqueous buffer solution.
Purification	Protein A affinity chromatography from HEK293 supernatants.
Shipping Temperature	-80°C (dry ice)
Storage Stability	Stable for at least 12 months at -80°C.

Product Manual	Datasheet

Reference	Takemura, S., et al., FEBS Letters, 2000; 476: 266-271.

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SKU	Supplier No.	Size	Your price	Quantity
BHA18200036	100186-1	50 ug	$379.50		Add to Cart

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