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Home / Primary Antibodies / Monoclonal Antibodies

Anti-CD28 Agonist Antibody

SKU : BHA18200035

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BPS Bioscience

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Mfr.No.	100182-2
Background	The T cell-specific receptor CD28 is an important regulator of the immune system. The ligation of CD28 and its ligands CD80/CD86 on the APC provides a critical costimulatory signal alongside T cell receptor (TCR) for T cell activation. The costimulatory signal can also be delivered by the interaction between CD28 and its agonist antibody. Anti-CD27 agonist antibody binds to CD27 on T cells and promotes T cell response. It represents new opportunities for cancer immunotherapy.
Clonality	Monoclonal
Description	Recombinant monoclonal antibody recognizing human CD28. This antibody binds to CD28 on T cells and promotes T cell response. Not tested in other species. assay conditions: Serial dilutions of anti-CD3 (BPS Bioscience, #71274) and CD28 antibodies were added to the IL-2 reporter-Jurkat cells, then incubated at 37°C incubator for 16 hrs. After the treatment, perform Luciferase assay using One-Step Luciferase assay system (BPS Bioscience, #60690)
Formulation	8 mM Na Phosphate pH 7.4, 110 mM NaCl, 2.2 mM KCl and 20% glycerol.
Isotype	IgG1
Molecular Weight	Heavy Chain: 51 kDa; Light Chain: 27 kDa
Species	Human
Synonyms	T-Cell-Specific Surface Glycoprotein, TP44, 100182-1, 100182-2
Note	Avoid freeze/thaw cycles.

Uniprot	P10747

Format	Aqueous buffer solution.
Purification	Protein A affinity chromatography from HEK293 supernatants.
Shipping Temperature	-80°C (dry ice)
Storage Stability	Stable for at least 12 months at -80°C. Store diluted antibody with carrier protein (BSA 0.1 - 0.5%) at 4°C, stable for 2 weeks.

Product Manual	Datasheet

Reference	Takemura, S., et al., FEBS Letters, 2000; 476: 266-271.

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SKU	Supplier No.	Size	Your price	Quantity
BHA18200035	100182-2	100 ug	$506		Add to Cart

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