CD2 is found as a surface antigen found on all peripheral blood T-cells and the majority of NK cells. It interacts with lymphocyte function-associated antigen (LFA-3/CD58) on antigen presenting cells to optimize immune recognition or CD48/BCM1 in rodents to mediate adhesion between T-cells and other cell types. CD2 also acts as a co-stimulatory molecule on T and NK cells and its cytoplasmic domain is implicated in the signaling function. As a specific marker for T and NK cells which is also expressed by the great majority of T cell lymphomas and leukaemias, CD2 can be used to distinguish these conditions from B cell neoplasms.
Host
Mouse
Immunogen
Human cytolytic T lymphocytes
Isotype
IgG1
Reactivity
Human
Recombinant
TRUE
Regulatory
RUO
Buffer
PBS, pH 7.4 with 0.05% sodium azide
Concentration
100µg/100µl
Description
Specificity: Human CD2
Format
Liquid
Purity
The antibody was affinity-purified from hybridoma supernatant by affinity-chromatography.
Storage
This product is stable for several weeks at 4°C as an undiluted liquid. Dilute only prior to immediate use. For extended storage, aliquot contents and freeze at -20°C or below. Avoid cycles of freezing and thawing. Expiration date is one (1) year from date of receipt.
Applications
WB, ELISA
Description
WB and ELISA: 1:500~1:1000. Optimal dilutions should be calculated by the end user based on their specific application., WB ; ELISA