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Home / Primary Antibodies / Monoclonal Antibodies

Anti-CD11b/ITAM

SKU : BHA15100314

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BioGenex Laboratories

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Mfr.No.	AN851-5M
Clonality	Monoclonal
Description	CD11b also known as ITAM (or) Integrin alpha-M or MAC-1 alpha subunit or CR3 alpha chain is member of the integrin alpha chain family, expressed predominately in human myeloid cells, follicular dendritic cells, NK1 cells, monocytes and granulocytes. The alpha subunit of ITAM/beta-2 complex (CD11b/CD18, Mac-1), is a receptor for fibrinogen, factor X, and ICAM1. ITAM/beta-2 is implicated in adhesive interactions of monocytes, macrophages, and granulocytes. CD11b has been used as a common myeloid marker. CD11b is expressed in about 50% of acute myeloid leukemia (AML). In combination with CD117, CD11b is helpful in differentiating acute promyelocytic leukemia (CD11b negative) from recovering benign myeloid proliferation (CD11b positive, CD117 negative). In acute promyelocytic leukemia patients treated with all-trans retinoic acid or Arsenic trioxide (As2O3), CD11b is a marker for differentiating the induction of leukemia cells. CD11b is also expressed on microglia cells and involved in the development of neurodegenerative diseases.
Host	Rabbit
Isotype	IgG
Reactivity	Human
Species	Rabbit

Clone No	EP45
Research Area	Infectious diseases, Immune system

Buffer	PBS
Concentration	1-3ug/ml
Storage	2-8°C

Applications	IHC
Dilution	1:50-80

Product Manual	Datasheet SDS

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Combination SKU	Supplier No.	Size	Your price	Quantity
AN851-5M	AN851-5M	6 mL	$237		Add to Cart
AN851-10M	AN851-10M	100 tests - i6000	$421		Add to Cart
AY851-50D	AY851-50D	50 tests - Xmatrx	$251		Add to Cart
AY851-YCD	AY851-YCD	160 tests - Xmatrx	$667		Add to Cart
NU851-UC	NU851-UC	1ml Conc	$438		Add to Cart
NU851-5UC	NU851-5UC	0.5ml Conc	$305		Add to Cart

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