Encoded by the KIT gene, the CD117 antigen is also known as c-Kit and stem cell factor receptor (SCFR). The CD117 antigen is expressed primarily on hematopoietic progenitor cells, mast cells and neural crest-derived melanocytes. CD117 is a type I transmembrane glycoprotein in the receptor tyrosine kinase (RTK) family which functions in the regulation of cell survival and proliferation, hematopoiesis, stem cell maintenance, gametogenensis, mast cell development, migration and function, and in melanogenesis. Mutations with the KIT gene are associated with diseases such as gastrointestinal stromal tumor and piebaldism.
Host
Mouse
Immunogen
Human erythroleukemia cell line OCIM1
Isotype
IgG2a
Reactivity
Human
Recombinant
FALSE
Regulatory
RUO
Buffer
PBS, pH 7.4 with 0.05% sodium azide
Concentration
100µg/100µl
Description
Specificity: Anti-CD117 Antibody recognizes human CD117.
Format
Liquid
Purity
The antibody was affinity-purified from hybridoma supernatant by affinity-chromatography.
Storage
This product is stable for several weeks at 4°C as an undiluted liquid. Dilute only prior to immediate use. For extended storage, aliquot contents and freeze at -20°C or below. Avoid cycles of freezing and thawing. Expiration date is one (1) year from date of receipt.