PC2 (Chromobox homolog 4, CBX4) is a member of Drosophila Polycomb group gene family. The polycomb group (PcG) genes are essential for maintenance of appropriate expression patterns of developmental master regulators and thus are essential for proper development. Changes in expression pf PcG proteins have been associated with cancer. PC2 is a part of the cellular memory system that is responsible for the inheritance of gene activity by progeny cells.
Host
Rabbit
Immunogen
Synthetic peptide conjugated to KLH
Isotype
IgG
Quantity
100 µl
Reactivity
Human
Recombinant
FALSE
Regulatory
RUO
Shipping Condition
Ice Packs
Buffer
PBS, pH 7.4 with 0.02% Sodium Azide
Concentration
100µg/100ul
Description
Specificity: Not tested with other proteinsRelevance: PC2 is involved in maintaining the transcriptionally repressive state of genes. It modifies chromatin, rendering it heritably changed in its expressibility. Structurally, PC2 contains 1 chromo domain. It was reported that PC2 is involved in sumoylation process by recruiting SUMO E1 and E2, and PC2 is actually SUMO E3 during sumoylation events. PC2 expression is ubiquitous.PC2 and other members of the Drosophila Polycomb group gene family are part of a cellular memory system that is responsible for the inheritance of gene activity by progeny cells
Format
Liquid
Purity
Purified
Storage
This product is stable for several weeks at 4°C as an undiluted liquid. Dilute only prior to immediate use. For extended storage, aliquot contents and freeze at -20°C or below. Avoid cycles of freezing and thawing. Expiration date is one (1) year from date of receipt.
Storage Condition
-20C
Applications
WB, ELISA
Description
Recommended dilutions Peptide ELISA: 1:10,000 WB: 1/100 - 1/500. Not yet tested in other applications. Optimal dilutions/concentrations should be determined by the end user, WB ; ELISA