Anti-CBL Antibody

Mfr.No.	Y058304
Categories	Primary Antibodies
Cellular Localization	Cytoplasmic
Clonality	polyclonal
Description	This gene is a proto-oncogene that encodes a RING finger E3 ubiquitin ligase. The encoded protein is one of the enzymes required for targeting substrates for degradation by the proteasome. This protein mediates the transfer of ubiquitin from ubiquitin conjugating enzymes (E2) to specific substrates. This protein also contains an N-terminal phosphotyrosine binding domain that allows it to interact with numerous tyrosine-phosphorylated substrates and target them for proteasome degradation. As such it functions as a negative regulator of many signal transduction pathways. This gene has been found to be mutated or translocated in many cancers including acute myeloid leukaemia. Mutations in this gene are also the cause of Noonan syndrome-like disorder. [provided by RefSeq, Mar 2012]
Host	Rabbit
Immunogen	Rabbit polyclonal CBL antibody was raised against a peptide from the intermediate residues of human CBL protein.
Isotype	IgG
Quantity	100 µl
Reactivity	Rat, Mouse, Human
Recombinant	FALSE
Regulatory	RUO
Shipping Condition	Ice Packs

Buffer	PBS, pH 7.4 with 0.02% Sodium Azide
Concentration	100µg/100ul
Format	Liquid
Purity	Peptide immunogen affinity purified
Storage	This product is stable for several weeks at 4°C as an undiluted liquid. Dilute only prior to immediate use. For extended storage, aliquot contents and freeze at -20°C or below. Avoid cycles of freezing and thawing. Expiration date is one (1) year from date of receipt.
Storage Condition	-20C

Applications

WB, IHC, ELISA

Description

For research use only
Peptide ELISA titer: 1:5,000-1:10,000
Western blot analysis: 1:200-1:1000
Immunohistochemistry: 1:50-200
Optimal dilutions/concentrations should be determined by the end use., WB ; IHC ; ELISA

Dilution

ELISA	1:5,000-1:10,000
WB	1:200-1:1000
IHC	1:50-200

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SKU	Supplier No.	Size	Your price	Quantity
BHA10900930	Y058304	100 ul	$217.50		Add to Cart

Anti-CBL Antibody

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