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Home / Primary Antibodies / Polyclonal Antibodies

Anti-Caspase-6/CASP6 Antibody Picoband®

SKU : BHA21001224

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Mfr.No.	A02631, A02631-10ug, A02631-Biotin, A02631-Cy3, A02631-Dylight488, A02631-Dylight550, A02631-Dylight594, A02631-FITC, A02631-HRP, A02631-APC, A02631-PE, A02631-iFluor647, A02631-carrier-free
Alternative Names	Caspase-6
Background	Caspase 6 is an enzyme that in humans is encoded by the CASP6 gene. This gene encodes a protein that is a member of the cysteine-aspartic acid protease (caspase) family. Using radiation hybrid mapping, the CASP6 gene is localized to human chromosome 4q25-q26. It functions as a downstream enzyme in the caspase activation cascade. And CASP6 can cleave lamin A to its signature apoptotic fragment.
Clonality	Polyclonal
Cross Reactivity	No cross-reactivity with other proteins.
Description	Boster Bio Anti-Caspase-6/CASP6 Antibody Picoband® catalog # A02631. Tested in WB applications. This antibody reacts with Human, Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Weste blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
Function	Involved in the activation cascade of caspases responsible for apoptosis execution. Cleaves poly (ADP-ribose) polymerase in vitro, as well as lamins. Overexpression promotes programmed cell death.
Host	Rabbit
Immunogen Region	E. coli-derived human Caspase-6 recombinant protein (Position: A194-N293). Human Caspase-6 shares 95.9% and 93.9% amino acid (aa) sequence identity with mouse and rat Caspase-6, respectively.
Isotype	Rabbit IgG
Molecular Weight	33 kDa
Reactivity	Human, Mouse, Rat
Reconstitution	Add 0.2ml of distilled water will yield a concentration of 500ug/ml.
Specificity	No cross reactivity with other proteins.
Synonyms	Caspase-6;CASP-6;3.4.22.59;Apoptotic protease Mch-2;Caspase-6 subunit p18;Caspase-6 subunit p11;CASP6;MCH2;
Tissue Specificity	Highly expressed in placenta, lung, kidney, testis and ovary. Weakly expressed in spleen and thymus. Not expressed in peripheral blood lymphocytes. Detected in hippocampus.
Note	Each vial contains 4 mg Trehalose, 0.9 mg NaCl and 0.2 mg Na2HPO4.

Uniprot	P55212
Gene Id	839
Gene Name	CASP6
Subcellular Location	Cytoplasm.

Conjugates	Biotin, Cy3, Dylight488, Dylight550, Dylight594, FITC, HRP, APC, PE, iFluor647, carrier-free

Concentration	Adding 0.2 ml of distilled water will yield a concentration of 500 ug/ml.
Form	Lyophilized
Purification	Immunogen affinity purified.
Storage	Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Applications	WB
Description	Weste blot, 0.1-0.5ug/ml, Mouse, Rat, Human<br>

Reference	1. Feandes-Alnemri, T., Litwack, G., Alnemri, E. S.Mch2, a new member of the apoptotic Ced-3/Ice cysteine protease gene family.Cancer Res. 55: 2737-2742, 1995.<br /><br />2. Nikolaev, A., McLaughlin, T., O'Leary, D. D. M., Tessier-Lavigne, M.APP binds DR6 to trigger axon pruning and neuron death via distinct caspases Nature 457: 981-989, 2009.<br /><br />3. Orth, K., Chinnaiyan, A. M., Garg, M., Froelich, C. J., Dixit, V. M.The CED-3/ICE-like protease Mch2 is activated during apoptosis and cleaves the death substrate lamin A.J. Biol. Chem. 271: 16443-16446, 1996.<br /><br />

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Combination SKU	Supplier No.	Size	Conjugation	Your price	Quantity
BHA21001224-1	A02631	100 ug	-	$370		Add to Cart
BHA21001224-2	A02631-10ug	10 ug	Sample	$99		Add to Cart
BHA21001224-3	A02631-Biotin	100 ug	Biotin	$570		Add to Cart
BHA21001224-4	A02631-Cy3	100 ug	Cy3	$570		Add to Cart
BHA21001224-5	A02631-Dylight488	100 ug	Dylight488	$570		Add to Cart
BHA21001224-6	A02631-Dylight550	100 ug	Dylight550	$570		Add to Cart
BHA21001224-7	A02631-Dylight594	100 ug	Dylight594	$570		Add to Cart
BHA21001224-8	A02631-FITC	100 ug	FITC	$570		Add to Cart
BHA21001224-9	A02631-HRP	100 ug	HRP	$570		Add to Cart
BHA21001224-10	A02631-APC	100 ug	APC	$670		Add to Cart
BHA21001224-11	A02631-PE	100 ug	PE	$670		Add to Cart
BHA21001224-12	A02631-iFluor647	100 ug	iFluor647	$670		Add to Cart
BHA21001224-13	A02631-carrier-free	100 ug	carrier-free	$370		Add to Cart

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