Anti-C-mAhi-1 M5 Antibody

Mfr.No.	Y030001
Categories	Primary Antibodies
Clonality	monoclonal
Description	Abelson helper integration site-1 (Ahi-1) is a novel oncogene identified based on its common activation in v-abl and myc-induced murine lymphomas. The murine Ahi-1 gene encodes a unique protein with multiple SH3 binding sites, an SH3 domain and multiple WD40-repeat domains. The conserved human homolog (AHI-1) contains an additional coiled-coil domain in its N-terminal region. Both murine and human Ahi-1/AHI-1 genes encode at least three isoforms and thus this gene is also subject to alternative splicing in normal cells. Expression of Ahi-1/AHI-1 is regulated at multiple stages of hematopoiesis in a highly conserved fashion in mouse and humans. It is highly elevated in certain human lymphoma and leukemia cells, including those from patients with cutaneous T-cell lymphomas (CTCL), BCR-ABL+ chronic myeloid leukemia (CML) and acute lymphoblastic leukemia (ALL). AHI-1 is also to be strongly expressed in embryonic hindbrain and forebrain, and AHI-1 may be required for both cerebellar and cortical development in humans. Defects in AHI-1 are the cause of Joubert syndrome, an autosomal recessive brain congenital malformation.
Host	Mouse
Immunogen	C-mAhi-1 M5 reacts with an epitope in the c-terminal region of mouse Ahi-1 protein. A recombinant mouse Ahi-1 GST fusion protein was used as immunogen. This antibody was purified from supernatant by affinity chromatography.
Isotype	IgG1
Quantity	100 µg
Reactivity	Mouse
Recombinant	FALSE
Regulatory	RUO
Shipping Condition	Ice Packs

Buffer	PBS, pH 7.4 with 0.02% sodium azide.
Concentration	100µg/100ul
Description	Specificity: It only specifically reacts with murine Ahi-1.
Format	Liquid
Purity	Affinity purified
Storage	This product is stable for several weeks at 4°C as an undiluted liquid. Dilute only prior to immediate use. For extended storage, aliquot contents and freeze at -20°C or below. Avoid cycles of freezing and thawing. Expiration date is one (1) year from date of receipt.
Storage Condition	-20C

Applications

WB, IHC

Description

Application include Western blot analysis (1: 1000-2000 dilution), immunoprecipitation ( 1-2 ug / 200-800 ug protein) and immunostaining of cultured cells (1: 200-1000 dilution)., WB ; IHC

Dilution

WB	1:1000-2000
Ist	1:200-1000
IP	1-2 ug/200-800 ug

No Description Available.

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SKU	Supplier No.	Size	Your price	Quantity
BHA10916956	Y030001	100 ug	$322.50		Add to Cart

Anti-C-mAhi-1 M5 Antibody

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