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Home / Primary Antibodies

Anti-BRCA1 (Phospho-Ser1524) Antibody

SKU : BHA10916694

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Applied Biological Materials (abm) Inc.

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Mfr.No.	Y011117
Categories	Primary Antibodies ; Phospho Antibodies
Clonality	polyclonal
Description	This gene encodes a nuclear phosphoprotein that plays a role in maintaining genomic stability, and it also acts as a tumor suppressor. The encoded protein combines with other tumor suppressors, DNA damage sensors, and signal transducers to form a large multi-subunit protein complex known as the BRCA1-associated genome surveillance complex (BASC). This gene product associates with RNA polymerase II, and through the C-terminal domain, also interacts with histone deacetylase complexes. This protein thus plays a role in transcription, DNA repair of double-stranded breaks, and recombination. Mutations in this gene are responsible for approximately 40% of inherited breast cancers and more than 80% of inherited breast and ovarian cancers. Alternative splicing plays a role in modulating the subcellular localization and physiological function of this gene. Many alternatively spliced transcript variants, some of which are disease-associated mutations, have been described for this gene, but the full-length natures of only some of these variants has been described. A related pseudogene, which is also located on chromosome 17, has been identified. [provided by RefSeq, May 2009]
Host	Rabbit
Immunogen	The antiserum was produced against synthesized phosphopeptide derived from human BRCA1 around the phosphorylation site of serine 1524 (Y-P-SP-Q-E).
Quantity	100 µg
Reactivity	Human
Recombinant	FALSE
Regulatory	RUO
Shipping Condition	Ice Packs

Buffer	phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Concentration	1µg/ul
Description	Specificity: BRCA1 (phospho-Ser1524) antibody detects endogenous levels of BRCA1 only when phosphorylated at serine 1524.
Format	Liquid
Purity	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific phosphopeptide. The antibody against non-phosphopeptide was removed by chromatography using non-phosphopeptide corresponding to the phosphorylation site.
Storage	This product is stable for several weeks at 4°C as an undiluted liquid. Dilute only prior to immediate use. For extended storage, aliquot contents and freeze at -20°C or below. Avoid cycles of freezing and thawing. Expiration date is one (1) year from date of receipt.
Storage Condition	-20C

Applications

IHC

Description

IHC: 1:50~1:100, IHC

Dilution

IHC	1:50-1:100~

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SKU	Supplier No.	Size	Your price	Quantity
BHA10916694	Y011117	100 ug	$427.50		Add to Cart

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