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Home / Primary Antibodies

Anti-BRCA1 Antibody

SKU : BHA10900136

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Applied Biological Materials (abm) Inc.

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Mfr.No.	Y300106
Categories	Primary Antibodies
Clonality	monoclonal
Description	BRCA1 is a nuclear phosphoprotein that plays a role in maintaining genomic stability. As a tumor suppressor, BRCA1 combines with other tumor suppressors, DNA damage sensors, and signal transducers to form a large multi-subunit protein complex known as the BRCA1-associated genome surveillance complex (BASC). BRCA1 associates with RNA polymerase II through the C-terminal domain, also interacts with histone deacetylase complexes. This protein thus plays a role in transcription, DNA repair of double-stranded breaks, and recombination. Mutations in BRCA1 gene are responsible for approximately 40% of inherited breast cancers and more than 80% of inherited breast and ovarian cancers. Other diseases associated with BRCA1 include primary peritoneal carcinoma.
Host	Mouse
Immunogen	A synthetic peptide corresponding to a sequence in the human BRCA1
Isotype	IgG1
Reactivity	Human
Recombinant	FALSE
Regulatory	RUO

Buffer	PBS, pH 7.4 with 0.05% sodium azide
Concentration	100µg/100µl
Description	Specificity: Human BRCA1
Format	Liquid
Purity	The antibody was affinity-purified from hybridoma supernatant by affinity-chromatography.
Storage	This product is stable for several weeks at 4°C as an undiluted liquid. Dilute only prior to immediate use. For extended storage, aliquot contents and freeze at -20°C or below. Avoid cycles of freezing and thawing. Expiration date is one (1) year from date of receipt.

Applications	IP
Description	Optimal dilutions should be calculated by the end user based on their specific application., IP

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SKU	Supplier No.	Size	Your price	Quantity
BHA10900136	Y300106	100 ul	$322.50		Add to Cart

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