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Home / Primary Antibodies / IHC Antibodies

Anti-BCR Antibody BHA11300220

SKU : BHA11300220

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Mfr.No.	BS1033
Alternative Names	Breakpoint cluster region protein ; Renal carcinoma antigen NY-REN-26 ; BCR ; BCR1 ; D22S11
Categories	Primary Antibodies
Chromosome Location	22q11.23
Clonality	polyclonal
Description	The Bcr gene, mapping on chromosome 22, was initially identified on the basis of its fusion with the c-Abl proto-oncogene on chromosome 9 resulting in the generation of the Philadelphia chromosome in 90-95% of patients with chronic myelogenous leukemia (CML). The Bcr gene encodes for the Breakpoint cluster region protein (Bcr). A consequence of this translocation is the generation of a Bcr/c-Abl mRNA encoding an activated c-Abl protein kinase. The Bcr gene has been shown to encode a 160 kDa GTPase-activating protein (GAP) specific for the Ras-related GTP-binding protein, Rac 1 p21. While it has been speculated that the Bcr protein may also stimulate Rac 2 p21 GTPase activity, it has no effect on Ras p21 or Rho p21 GTPases.
Host	Rabbit
Immunogen	Synthetic peptide, corresponding to amino acids 141-190 of Human Bcr.
Reactivity	Human, Mouse, Rat
Recombinant	FALSE
Regulatory	RUO
Species	Homo Sapiens (Human)

Swissprot	P11274
Uniprot	P11274
Weight	160 kDa

Description	Product: 1 mg/ml in Phosphate buffered saline (PBS) with 0.05% sodium azide, approx. pH 7.2. Specificity: Bcr (D171) polyclonal antibody detects endogenous levels of Bcr protein.
Purity	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Storage	Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Applications

WB, IHC

Description

WB ; IHC

Dilution

WB	1:500-1:1000
IHC	1:50-1:200

Datasheet

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SKU	Supplier No.	Size	Your price	Quantity
BHA11300220	BS1033	50µl	$190.44		Add to Cart
BHA11300220	BS1033	100µl	$294.44		Add to Cart

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