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Home / Primary Antibodies

Anti-BAFF(B cell activating factor) Antibody

BHA10917936
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Contact us to order
Tel
+1 866.986.9598
Email
orders@biohippo.com
Get a Quote
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Buffer PBS, pH 7.4 with 0.02% sodium azide.
Concentration 100µg/100ul
Description Specificity: This Polyclonal antibody is directed against human BAFF protein. The product was purified from serum by protein A chromatography. Expect reactivity with human BAFF. Cross-reactivity with BAFF from other sources has not been determined.
Relevance: Members of the TNF superfamily regulate immune responses and induce apoptosis. A novel member in the TNF family was recently identified by several groups and designated BAFF (for B cell Activating Factor belonging to the TNF Family), BLyS (for B Lymphocyte Stimulator), TALL1 (for TNF- and ApoL- related Leukocyte-expressed Ligand), and THANK (for TNF Homologue that Activate Apoptosis, NFkB and c-jun N-terminal Kinase). BAFF/BLyS was characterized as a B cell stimulator since it induced B cell proliferation and immunoglobulin secretion. Two receptors for BAFF were recently identified and designated TACI and BCMA. BAFF also signals through a third TNF receptor BAFFR/BR3. BAFF and its receptors are involved in the development of systemic lupus erythaematosus and other B cell associated autoimmune diseases. Like TNFa and TRAIL, THANK was shown to activate NF-kB and c-jun N terminal kinase (JNK) and to induce apoptosis. The human BAFF gene codes for a 285 amino acid type II transmembrane protein containing a 46 amino acid cytoplasmic domain, a 21 amino acid transmembrane domain, and a 218 amino acid extracellular domain.
Format Liquid
Purity Affinity purified
Storage This product is stable for several weeks at 4°C as an undiluted liquid. Dilute only prior to immediate use. For extended storage, aliquot contents and freeze at -20°C or below. Avoid cycles of freezing and thawing. Expiration date is one (1) year from date of receipt.
Storage Condition -20C
Applications WB
Description Recommended dilutions
WB: 1/500~3000
Predicted molecular weight: 31 kDa.
Not yet tested in other applications.
Optimal dilutions/concentrations should be determined by the end user., WB
Dilution

WB1:500~3000
SKU Supplier No. Size Your price Quantity
BHA10917936 Y080099 100 ul $187.50
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