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Home / Primary Antibodies / Polyclonal Antibodies

Anti-Aquaporin 4/AQP4 Antibody Picoband®

SKU : BHA21000371

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Mfr.No.	PB9475, PB9475-10ug, PB9475-Biotin, PB9475-Cy3, PB9475-Dylight488, PB9475-Dylight550, PB9475-Dylight594, PB9475-FITC, PB9475-HRP, PB9475-APC, PB9475-PE, PB9475-iFluor647, PB9475-carrier-free
Alternative Names	Aquaporin-4
Background	Aquaporin 4 is found in the basolateral cell membrane of principal collecting duct cells and provides a pathway for water to exit these cells. The gene of AQP4 is mapped to 18q11.2-q12.1. Similar to other aquaporins, the AQP4 gene is composed of 4 exons encoding 127, 55, 27, and 92 amino acids separated by introns of 0.8, 0.3, and 5.2 kb. Unlike other aquaporins, an alteative coding initiation sequence (designated exon 0) was located 2.7 kb upstream of exon 1. When spliced together, M1 and the subsequent 10 amino acids are encoded by exon 0; the next 11 amino acids and M23 are encoded by exon 1. AQP4 is expressed in astrocytes and is upregulated by insult to the central nervous system. And AQP4 is the predominant water channel in the brain and has an important role in brain water homeostasis. It is abundant in mammalian brain and is concentrated in astrocytic foot processes at the blood-brain barrier.
Clonality	Polyclonal
Cross Reactivity	No cross-reactivity with other proteins
Description	Boster Bio Anti-Aquaporin 4/AQP4 Antibody Picoband® catalog # PB9475. Tested in IHC, WB applications. This antibody reacts with Human, Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Weste blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
Function	Forms a water-specific channel. Osmoreceptor which regulates body water balance and mediates water flow within the central nervous system.
Host	Rabbit
Immunogen Region	A synthetic peptide corresponding to a sequence at the C-terminus of human Aquaporin 4, different from the related mouse sequence by two amino acids, and from the related rat sequence by three amino acids.
Isotype	Rabbit IgG
Molecular Weight	37 kDa
Reactivity	Human, Mouse, Rat
Reconstitution	Add 0.2ml of distilled water will yield a concentration of 500ug/ml.
Specificity	No cross reactivity with other proteins.
Synonyms	Aquaporin-4;AQP-4;Mercurial-insensitive water channel;MIWC;WCH4;AQP4;
Tissue Specificity	Brain - muscle >> heart, kidney, lung, and trachea.
Note	Each vial contains 4 mg Trehalose, 0.9 mg NaCl and 0.2 mg Na2HPO4.

Uniprot	P55087
Gene Id	361
Gene Name	AQP4
Sequence	Belongs to the MIP/aquaporin (TC 1.A.8) family.
Subcellular Location	Membrane; Multi-pass membrane protein.

Conjugates	Biotin, Cy3, Dylight488, Dylight550, Dylight594, FITC, HRP, APC, PE, iFluor647, carrier-free

Concentration	Adding 0.2 ml of distilled water will yield a concentration of 500 ug/ml.
Form	Lyophilized
Purification	Immunogen affinity purified.
Storage	Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Applications	IHC, WB
Description	Weste blot, 0.1-0.5ug/ml, Mouse, Rat Immunohistochemistry (Paraffin-embedded Section), 2-5ug/ml, Human, Mouse, Rat, By Heat Immunohistochemistry (Frozen Section), 0.5-1ug/ml, Mouse, Rat

Reference	1. Amiry-Moghaddam, M.; Otsuka, T.; Hu, P. D.; Traystman, R. J.; Haug, F.-M.; Froehner, S. C.; Adams, M. E.; Neely, J. D.; Agre, P.; Ottersen, O. P.; Bhardwaj, A. : An alpha-syntrophin-dependent pool of AQP4 in astroglial end-feet confers biional water flow between blood and brain. Proc. Nat. Acad. Sci. 100: 2106-2111, 2003. 2. Agre P, Nielsen S (1996). "The aquaporin family of water channels in kidney". Nephrologie 17 (7): 40915. 3. Lennon, V. A.; Kryzer, T. J.; Pittock, S. J.; Verkman, A. S.; Hinson, S. R. : IgG marker of optic-spinal multiple sclerosis binds to the aquaporin-4 water channel. J. Exp. Med. 202: 473-477, 2005. 4. Lu, M.; Lee, M. D.; Smith, B. L.; Jung, J. S.; Agre, P.; Verdijk, M. A. J.; Merkx, G.; Rijss, J. P. L.; Deen, P. M. T. : The human AQP4 gene: definition of the locus encoding two water channel polypeptides in brain. Proc. Nat. Acad. Sci. 93: 10908-10912, 1996. 5. Nagelhus EA, Mathiisen TM, Ottersen OP (2004). "Aquaporin-4 in the central nervous system: cellular and subcellular distribution and coexpression with KIR4.1". Neuroscience 129 (4): 90513.

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Combination SKU	Supplier No.	Size	Conjugation	Your price	Quantity
BHA21000371-1	PB9475	100 ug	-	$370		Add to Cart
BHA21000371-2	PB9475-10ug	10 ug	Sample	$99		Add to Cart
BHA21000371-3	PB9475-Biotin	100 ug	Biotin	$570		Add to Cart
BHA21000371-4	PB9475-Cy3	100 ug	Cy3	$570		Add to Cart
BHA21000371-5	PB9475-Dylight488	100 ug	Dylight488	$570		Add to Cart
BHA21000371-6	PB9475-Dylight550	100 ug	Dylight550	$570		Add to Cart
BHA21000371-7	PB9475-Dylight594	100 ug	Dylight594	$570		Add to Cart
BHA21000371-8	PB9475-FITC	100 ug	FITC	$570		Add to Cart
BHA21000371-9	PB9475-HRP	100 ug	HRP	$570		Add to Cart
BHA21000371-10	PB9475-APC	100 ug	APC	$670		Add to Cart
BHA21000371-11	PB9475-PE	100 ug	PE	$670		Add to Cart
BHA21000371-12	PB9475-iFluor647	100 ug	iFluor647	$670		Add to Cart
BHA21000371-13	PB9475-carrier-free	100 ug	carrier-free	$370		Add to Cart

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