Anti-APBA1 Antibody

Mfr.No.	Y058068
Categories	Primary Antibodies
Cellular Localization	Cytoplasmic
Clonality	polyclonal
Description	The protein encoded by this gene is a member of the X11 protein family. It is a neuronal adaptor protein that interacts with the Alzheimer's disease amyloid precursor protein (APP). It stabilises APP and inhibits production of proteolytic APP fragments including the A beta peptide that is deposited in the brains of Alzheimer's disease patients. This gene product is believed to be involved in signal transduction processes. It is also regarded as a putative vesicular trafficking protein in the brain that can form a complex with the potential to couple synaptic vesicle exocytosis to neuronal cell adhesion.
Host	Rabbit
Immunogen	Synthetic peptide conjugated to KLH
Isotype	IgG
Quantity	100 µl
Reactivity	Mouse, Human
Recombinant	FALSE
Regulatory	RUO
Shipping Condition	Ice Packs

Buffer	PBS, pH 7.4 with 0.02% Sodium Azide
Concentration	100µg/100ul
Description	Specificity: APBA1 antibody detects endogenous levels of APBA1 protein. Not tested with other proteins Relevance: APBA1 is part of two multimeric complexes, the first containing Munc18-1 and syntaxin 1 and the second being a brain specific heterotrimeric complex with LIN-10/X11-alpha, LIN-2/CASK, and LIN7. It binds to the cytoplasmic domain of amyloid protein (APP). ABPA1 has a putative function in synaptic vesicle exocytosis by binding to Munc18-1, an essential component of the synaptic vesicle exocytotic machinery. It may modulate processing of the beta amyloid precursor protein (APP) and hence formation of beta APP
Format	Liquid
Purity	Protein A purified
Storage	This product is stable for several weeks at 4°C as an undiluted liquid. Dilute only prior to immediate use. For extended storage, aliquot contents and freeze at -20°C or below. Avoid cycles of freezing and thawing. Expiration date is one (1) year from date of receipt.
Storage Condition	-20C

Applications

WB, ELISA

Description

Recommended dilutions Peptide ELISA: 1:20,000 WB: 1/200 - 1/1000 Not yet tested in other applications. Optimal dilutions/concentrations should be determined by the end user, WB ; ELISA

Dilution

ELISA	1:20,000
WB	1:200-1:1000

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SKU	Supplier No.	Size	Your price	Quantity
BHA10918095	Y058068	100 ul	$217.50		Add to Cart

Anti-APBA1 Antibody

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