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Home / Primary Antibodies / Polyclonal Antibodies

Anti-Angiotensin II Receptor Type-1 (extracellular)-ATTO Fluor-550 Antibody

SKU : BHA21300018

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Alomone Labs

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Mfr.No.	AAR-011-AO, AAR-011-AO_50 mcl
Lead Time	1-2 Business Days
Immunogen Species	Human
Background	Angiotensin II receptor type 1 (AT1, AGTR1) is one of the receptors that binds the octapeptide hormone Angiotensin II (Ang II). Ang II is the peptide hormone that generates most of the known effects of the renin-angiotensin system (RAS). Ang II is generated from the angiotensinogen protein by the actions of renin, angiotensin converting enzyme (ACE) and other peptidases. Ang II has a central role in cardiovascular homeostasis by regulating vasoconstriction, renal Na+ and water readsorption. In addition, Ang II induces cell growth and proliferation and has pro-inflammatory effects. Most of the physiological actions of Ang II are mediated by AT1 a member of the 7-transmembrane domain, G protein-coupled receptor (GPCR) superfamily.The AT1 receptor is coupled to a Gq/11 protein that activates phospholipase C (PLC) and leads to production of inositol 1,4,5-trisphosphate (InsP3) and intracellular Ca2+ mobilization. In addition to the rapid actions mediated by InsP3 and Ca2+ signaling, AT1 receptor elicits other signaling responses including activation of the MAPK and Jak/STAT. Together, these signaling pathways mediate most of Ang II cellular responses that include, control of hormone secretion, regulation of cell growth and apoptosis, regulation of ion channels activation and cell migration. In accordance with the pleiotropic actions of Ang II, the AT1 receptor has a wide distribution with high levels detected in the adrenal gland, kidney, brain, heart, liver, etc. As is the case with many other peptide receptors, the AT1 receptor undergoes ligand-induced endocytosis, a process that contributes to receptor desensitization and sequestration and contributes to regulate receptor signaling.
Clonality	Polyclonal
Description	Anti-Angiotensin II Receptor Type-1 (extracellular) Antibody (#AAR-011) is a highly specific antibody directed against an extracellular epitope of human protein. The antibody can be used in western blot, immunohistochemistry, immunocytochemistry and indirect flow cytometry applications, and will recognize AT1 receptor from rat, mouse and human samples. Anti-Angiotensin II Receptor Type-1 (extracellular)-ATTO Fluor-550 Antibody (#AAR-011-AO) is directly labeled with an ATTO-550 fluorescent dye. ATTO dyes are characterized by strong absorption (high extinction coefficient), high fluorescence quantum yield, and high photo-stability. The ATTO-550 fluorescent label is related to the well known dye Rhodamine 6G and can be used with filters typically used to detect Rhodamine. Anti-Angiotensin II Receptor Type-1 (extracellular)-ATTO Fluor-550 Antibody has been tested in immunocytochemistry and immunohistochemistry applications and is especially suited for experiments requiring simultaneous labeling of different markers.
Formulation	PBS pH7.4, 1% BSA with 0.05% sodium azide
Host	Rabbit
Immunogen Region	Extracellular, N-terminus
Isotype	Rabbit IgG
Reactivity	Human, Rat, Mouse
Reconstitution	50 ul double distilled water (DDW).
Shipping	Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C
Synonyms	AT1 Receptor, AT1R, AGTR1
UNSPSC Code	41116161
Note	Homology: Mouse, rat, rabbit, dog - identical Peptide confirmation: Confirmed by amino acid analysis and mass spectrometry Negative Control: RIC-001-AO Specifictiy: AGTR1 Is Toxin: No Standard quality control of each lot: Western blot analysis (unlabeled antibody, #AAR-011), and immunohistochemistry (labeled antibody). Antigen preadsorption control: 1 ug peptide per 1 ug antibody

Accession Number	P30556
Gene Id	185
Target	AT1 Receptor, AT1R, AGTR1
Sequence	NSSTEDGIKRIQDDC, corresponding to amino acid residues 4-18 of human AT1 receptor

Conjugates	ATTO-550. Maximum absorption 554 nm; maximum fluorescence 576 nm. The fluorescence is excited most efficiently in the 540 - 565 nm range. This label is related to the dye Rhodamine 6G and can be used with filters used to detect Rhodamine.

Concentration	1 mg/ml
Form	Lyophilized powder
Preservative	1% BSA, 0.05% NaN3
Purity	Affinity purified on immobilized antigen.
Storage	Storage After Reconstitution: The reconstituted solution can be stored at 4°C, protected from the light, for up to 1 week. For longer periods, small aliquots should be stored at -20°C. Avoid multiple freezing and thawing. Centrifuge all antibody preparations before use (10000 x g 5 min). Storage Before Reconstitution: The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20°C

Applications	IC, IF, IHC, LCI
Dilution	Immunohistochemistry paraffin embedded sections ihc: 1:50-1:60 Western blot wb: Contact Biohippo for information

Product Manual	SDS

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Combination SKU	Supplier No.	Size	Your price	Quantity
BHA21300018-1	AAR-011-AO_50 mcl	50 mcl	$797		Add to Cart

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