Anti-Alkaline Phosphatase (Tissue-Nonspecific) Antibody BHA10201307

Mfr.No.	249-MSM1-P1ABX
Alternative Names	Alkaline phosphatase, ; Alkaline phosphatase, testicular and thymus ; Alkaline phosphatase liver/bone/kidney ; Alkaline phosphatase, tissue-nonspecific ; ALPG ; ALPL ; Germ cell alkaline phosphatase ; Testicular and thymus alkaline phosphatase ; Tissue non-specific alkaline phosphatase ; Tissue nonspecific ALP (TNAP or TNSALP)
Categories	Primary Antibodies
Cellular Localization	Cell Surface
Chromosome Location	1p36.12
Clonality	Monoclonal
Description	There are at least four distinct but related alkaline phosphatases: intestinal, placental, placental-like, and liver/bone/kidney (tissue non-specific). The first three are located together on chromosome 2, while the tissue non-specific form is located on chromosome 1. The product of this gene is a membrane bound glycosylated enzyme that is not expressed in any particular tissue and is, therefore, referred to as the tissue-nonspecific form of the enzyme. The exact physiological function of the alkaline phosphatases is not known. A proposed function of this form of the enzyme is matrix mineralization; however, mice that lack a functional form of this enzyme show normal skeletal development. This enzyme has been linked directly to hypo-phosphatasia, a disorder that is characterized by hypercalcemia and includes skeletal defects. The character of this disorder can vary, however, depending on the specific mutation since this determines age of onset and severity of symptoms. Alternatively spliced transcript variants, which encode the same protein, have been identified for this gene.
Host	Mouse
Immunogen	Recombinant human ALPL protein
Isotype	IgG1 Kappa
Positive Control	Intestine
Reactivity	Human, Cow
Recombinant	FALSE
Regulatory	RUO

Swissprot	P05186
Uniprot	75431
Gene Id	249

Buffer	200μg/ml of Ab purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.
Concentration	1.0mg/ml
Description	There are no warranties, expressed or implied, which extend beyond this description. Company is not liable for any personal injury or economic loss resulting from this product.
Purity	Purified Ab WITHOUT BSA and Azide at 1.0mg/ml

Applications

FACS, IF, IHC-F

Description

(Staining of formalin-fixed tissues requires boiling tissue sections in 10mM Tris with 1mM EDTA, pH 9.0, for 10-20 min followed by cooling at RT for 20 minutes);,Optimal dilution for a specific application should be determined., FACS ; IF ; IHC-F

Dilution