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Home / Primary Antibodies / Monoclonal Antibodies

Anti-Aldolase/ALDOA Antibody Picoband® (monoclonal, 6H8)

SKU : BHA21003099

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Mfr.No.	M05022-2, M05022-2-10ug, M05022-2-Biotin, M05022-2-Cy3, M05022-2-Dylight488, M05022-2-Dylight550, M05022-2-Dylight594, M05022-2-FITC, M05022-2-HRP, M05022-2-APC, M05022-2-PE, M05022-2-iFluor647, M05022-2-carrier-free
Alternative Names	cofilin 2
Background	Aldolase A (ALDOA, or ALDA), also known as fructose-bisphosphate aldolase, is an enzyme that in humans is encoded by the ALDOA gene on chromosome 16. This gene encodes a member of the class I fructose-bisphosphate aldolase protein family. The encoded protein is a glycolytic enzyme that catalyzes the reversible conversion of fructose-1,6-bisphosphate to glyceraldehyde 3-phosphate and dihydroxyacetone phosphate. Three aldolase isozymes (A, B, and C), encoded by three different genes, are differentially expressed during development. Mutations in this gene have been associated with Glycogen Storage Disease XII, an autosomal recessive disorder associated with hemolytic anemia. Disruption of this gene also plays a role in the progression of multiple types of cancers. Related pseudogenes have been identified on chromosomes 3 and 10.
Clonality	Monoclonal
Cross Reactivity	No cross-reactivity with other proteins.
Description	Boster Bio Anti-Aldolase/ALDOA Antibody Picoband® (monoclonal, 6H8) catalog # M05022-2. Tested in Flow Cytometry, IF, IHC, ICC, WB applications. This antibody reacts with Human. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Weste blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
Function	Controls reversibly actin polymerization and depolymerization in a pH-sensitive manner. Its F-actin depolymerization activity is regulated by association with CSPR3. It has the ability to bind G- and F-actin in a 1:1 ratio of cofilin to actin. It is the m
Host	Mouse
Immunogen Region	E.coli-derived human Aldolase/ALDOA recombinant protein (Position: E50-Y364).
Isotype	Mouse IgG2b
Molecular Weight	39 kDa
Reactivity	Human
Reconstitution	Add 0.2ml of distilled water will yield a concentration of 500ug/ml.
Synonyms	Cofilin-2; Cofilin, muscle isoform; CFL2
Tissue Specificity	Isoform CFL2b is expressed predominantly in skeletal muscle and heart. Isoform CFL2a is expressed in various tissues.
Note	Each vial contains 4mg Trehalose, 0.9mg NaCl and 0.2mg Na2HPO4.

Uniprot	P04075
Gene Id	226
Gene Name	ALDOA
Clone No	Clone: 6H8
Subcellular Location	Cytoskeleton. Nucleus matrix.

Conjugates	Biotin, Cy3, Dylight488, Dylight550, Dylight594, FITC, HRP, APC, PE, iFluor647, carrier-free

Concentration	Adding 0.2 ml of distilled water will yield a concentration of 500 ug/ml.
Form	Lyophilized
Purification	Immunogen affinity purified.
Storage	Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Applications	WB, IHC, ICC, IF, Flow Cytometry
Description	Weste blot, 0.25-0.5ug/ml, Human<br> Immunohistochemistry (Paraffin-embedded Section), 2-5ug/ml, Human<br> Immunocytochemistry/Immunofluorescence, 5ug/ml, Human<br> Flow Cytometry (Fixed), 1-u?g/1x10<sup>6</sup> cells, Human<br>

Reference	1. Du, S; Guan, Z; Hao, L; Song, Y; Wang, L; Gong, L; Liu, L; Qi, X; Hou, Z; Shao, S (2014). "Fructose-bisphosphate aldolase a is a potential metastasis-associated marker of lung squamous cell carcinoma and promotes lung cell tumorigenesis and migration". PLOS ONE. 9 (1): e85804.<br /><br />2. Yao, DC; Tolan, DR; Murray, MF; Harris, DJ; Darras, BT; Geva, A; Neufeld, EJ (15 March 2004). "Hemolytic anemia and severe rhabdomyolysis caused by compound heterozygous mutations of the gene for erythrocyte/muscle isozyme of aldolase, ALDOA(Arg303X/Cys338Tyr)". Blood. 103 (6): 24013.<br /><br />3. St-Jean, M; Izard, T; Sygusch, J (11 May 2007). "A hydrophobic pocket in the active site of glycolytic aldolase mediates interactions with Wiskott-Aldrich syndrome protein". The Joual of Biological Chemistry. 282 (19): 1430915.

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Combination SKU	Supplier No.	Conjugation	Size	Your price	Quantity
BHA21003099-1	M05022-2	-	100 ug	$370		Add to Cart
BHA21003099-2	M05022-2-10ug	Sample	10 ug	$99		Add to Cart
BHA21003099-3	M05022-2-Biotin	Biotin	100 ug	$570		Add to Cart
BHA21003099-4	M05022-2-Cy3	Cy3	100 ug	$570		Add to Cart
BHA21003099-5	M05022-2-Dylight488	Dylight488	100 ug	$570		Add to Cart
BHA21003099-6	M05022-2-Dylight550	Dylight550	100 ug	$570		Add to Cart
BHA21003099-7	M05022-2-Dylight594	Dylight594	100 ug	$570		Add to Cart
BHA21003099-8	M05022-2-FITC	FITC	100 ug	$570		Add to Cart
BHA21003099-9	M05022-2-HRP	HRP	100 ug	$570		Add to Cart
BHA21003099-10	M05022-2-APC	APC	100 ug	$670		Add to Cart
BHA21003099-11	M05022-2-PE	PE	100 ug	$670		Add to Cart
BHA21003099-12	M05022-2-iFluor647	iFluor647	100 ug	$670		Add to Cart
BHA21003099-13	M05022-2-carrier-free	carrier-free	100 ug	$370		Add to Cart

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