Anti-ADCY6 Antibody

Mfr.No.	Y058019
Categories	Primary Antibodies
Cellular Localization	Membrane; multi-pass membrane protein
Clonality	polyclonal
Description	This gene encodes adenylate cyclase 6, which is a membrane-associated enzyme and catalyzes the formation of the secondary messenger cyclic adenosine monophosphate (cAMP). The expression of this gene is found in normal thyroid and brain tissues, as well as some tumors; and its expression is significantly higher in one hyperfunctioning thyroid tumor than in normal thyroid tissue. Alternative splicing generates 2 transcript variants.
Host	Rabbit
Immunogen	Synthetic peptide conjugated to KLH
Isotype	IgG
Quantity	100 µl
Reactivity	Human
Recombinant	FALSE
Regulatory	RUO
Shipping Condition	Ice Packs

Buffer	PBS, pH 7.4 with 0.02% Sodium Azide
Concentration	100µg/100ul
Description	Specificity: Not tested with other proteins Relevance: The membrane-bound adenylyl cyclases (ACs) represent one of the major families of effector enzymes for G protein-coupled receptors. Eight human AC isoforms (AC1 through AC4), encoded by separate genes, have been identified up to now. Most of the adenylate cyclase genes are comprise of 11-26 exons and distributed over a q6-430 kb. Majority of the adenylate cyclases previously described are expressed discretely in defined peripheral tissues, the type 4 adenylate cyclase (AC4) is apparently expressed in a variety of peripheral tissues and in the central nervous system, mainly in olfactory system. AC5 is localized on photoreceptor cells and are also designated as GC1 and GC2. The AC5 protein resembles the other adenylyl cyclases in its predicted and proposed structure. AC5 resembles the type 6 (AC6) adenylyl cyclase in its amino acid sequence but becomes divergent at N and C-terminal ends. The AC5 and AC6 proteins are co-localized in most of the visual organs (photoreceptor cells) are associated with other protein complexes. Both AC5 and AC6 enzymes play an important role in synaptic plasticity by coordinating overlapping synaptic inputs from Gs and Gi coupled receptor stimulation.
Format	Liquid
Purity	Purified
Storage	This product is stable for several weeks at 4°C as an undiluted liquid. Dilute only prior to immediate use. For extended storage, aliquot contents and freeze at -20°C or below. Avoid cycles of freezing and thawing. Expiration date is one (1) year from date of receipt.
Storage Condition	-20C

Applications

WB, ELISA

Description

Recommended dilutions Peptide ELISA: 1:160,000 . WB: 1/200 - 1/1000. Not yet tested in other applications. Optimal dilutions/concentrations should be determined by the end user, WB ; ELISA

Dilution

ELISA	1:160,000
WB	1:200-1:1000

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SKU	Supplier No.	Size	Your price	Quantity
BHA10915543	Y058019	100 ul	$217.50		Add to Cart

Anti-ADCY6 Antibody

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