Anti-ADAM20 Antibody

Mfr.No.	Y058013
Categories	Primary Antibodies
Cellular Localization	Membrane; single-pass type I membrane protein
Clonality	polyclonal
Description	This gene encodes a member of the ADAM (a disintegrin and metalloprotease domain) family. Members of this family are membrane-anchored proteins structurally related to snake venom disintegrins, and have been implicated in a variety of biological processes involving cell-cell and cell-matrix interactions, including fertilization, muscle development, and neurogenesis. The expression of this gene is testis-specific.
Host	Rabbit
Immunogen	Synthetic peptide conjugated to KLH
Isotype	IgG
Quantity	100 µl
Reactivity	Human
Recombinant	FALSE
Regulatory	RUO
Shipping Condition	Ice Packs

Buffer	PBS, pH 7.4 with 0.02% Sodium Azide
Concentration	100µg/100ul
Description	Specificity: Not tested with other proteins Relevance: ADAM20 was first cloned from a human testis library as a protein with homology to the fertilins (ADAMs 1, 2). ADAM20 message was seen predominantly in testis, but also at lower levels in placenta and B-cells. ADAM20 is closely related to ADAM21 (61% identical), ADAM29 (52% identical), and the testases (49-46% identical). ADAM20 contains the canonical HExxHxxxxxH zinc metalloproteinase motif, and the initial partial sequence of ADAM21 contained a non-functional catalytic site, making it tempting to speculate that ADAM20 and ADAM21 are orthologs to ADAMs 1&2. Later, a full-length ADAM21 sequence demonstrated a functional catalytic domain, but it may still be that the catalytically dead form of ADAM21 is expressed and functions as a fettilin. A member of the metalloproteinase family containing disintegrin-like domains (ADAMs) the function of ADAM20 is still poorly understood. Other ADAMs family members (ADAM10, ADAM17) have been more thoroughly studied, and are known to play key roles in inflammation, growth factor maturation and release, and a wide range of other functions. The full length ADAM20 sequence codes for a 726 amino acid protein, with a predicted mass is 81.711 kD. The sequence containing a Type-I transmembrane domain, metalloproteinase domain, cystein-rich domain, and a short cytoplasmic domain. Unlike many of the other ADAMs proteases, ADAM20 does not appear to contain a furin cleavage site.
Format	Liquid
Purity	Purified
Storage	This product is stable for several weeks at 4°C as an undiluted liquid. Dilute only prior to immediate use. For extended storage, aliquot contents and freeze at -20°C or below. Avoid cycles of freezing and thawing. Expiration date is one (1) year from date of receipt.
Storage Condition	-20C

Applications

WB, ELISA

Description

Recommended dilutions Peptide ELISA: 1:160,000 WB: 1/500 - 1/1000. Not yet tested in other applications. Optimal dilutions/concentrations should be determined by the end user, WB ; ELISA

Dilution

ELISA	1:160,000
WB	1:500-1:1000

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SKU	Supplier No.	Size	Your price	Quantity
BHA10917807	Y058013	100 ul	$217.50		Add to Cart

Anti-ADAM20 Antibody

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